Sugi Predict

Sugi Predict / Compounds / SCHEMBL9879189

SCHEMBL9879189

SCHEMBL9879189

CC(C)NC(=O)c1cc(N)c(F)cc1Cl

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ SMN1; SMN2 Q16637 2/20 0.51
▸ HPGD P15428 2/20 0.51
▸ MAPT P10636 2/20 0.51
▸ LMNA P02545 1/20 0.51
▸ POLB P06746 1/20 0.46
▸ APEX1 P27695 1/20 0.46
▸ ALOX5 P09917 1/20 0.45
▸ MEN1 O00255 1/20 0.45
▸ KMT2A Q03164 1/20 0.45
▸ KCNA3 P22001 1/20 0.43
▸ NPC1 O15118 3/20 0.42
▸ RAB9A P51151 3/20 0.42
▸ ALPL P05186 1/20 0.42
▸ ALDH1A1 P00352 1/20 0.40
▸ GAA P10253 1/20 0.40
▸ PRKCZ Q05513 1/20 0.39
▸ HTT P42858 1/20 0.39
▸ RECQL P46063 1/20 0.39
▸ ALOX15 P16050 1/20 0.38
▸ EIF2S1 P05198 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23243628 0.83 ALOX5 (0.46) SMN1; SMN2HPGDMAPTLMNAALOX5
SCHEMBL23266520 0.82 POLB (0.50) SMN1; SMN2HPGDMAPTPOLBAPEX1
SCHEMBL3528669 0.79 GAA (0.53) SMN1; SMN2HPGDMAPTLMNAPOLB
SCHEMBL6740081 0.78 LMNA (0.45) SMN1; SMN2HPGDMAPTLMNAPOLB
SCHEMBL16987346 0.78 HPGD (0.51) SMN1; SMN2HPGDMAPTLMNAPOLB
SCHEMBL10481251 0.78 MAPT (0.51) SMN1; SMN2HPGDMAPTLMNAPOLB
SCHEMBL26563572 0.76 POLB (0.40) SMN1; SMN2HPGDMAPTLMNAPOLB
SCHEMBL713577 0.76 SCN9A (0.46) POLBAPEX1
SCHEMBL8879615 0.76 POLB (0.42) SMN1; SMN2HPGDMAPTLMNAPOLB
Methylamine SCHEMBL7262148 0.75 KCNA3 (0.45) SMN1; SMN2HPGDMAPTLMNAALOX5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4371987-B9 SUBSTITUTED 6-AZABENZIMIDAZOLE COMPOUNDS AS HPK1 INHIBITORS GILEAD SCIENCES INC (US) 2025-11-26 — — EP disclosed
EP-4371987-B1 SUBSTITUTED 6-AZABENZIMIDAZOLE COMPOUNDS AS HPK1 INHIBITORS GILEAD SCIENCES INC (US) 2025-09-17 — — EP disclosed
US-12258346-B2 Substituted 6-azabenzimidazole compounds GILEAD SCIENCES, INC. (US) 2025-03-25 — — US disclosed
US-20240287061-A1 SUBSTITUTED 6-AZABENZIMIDAZOLE COMPOUNDS GILEAD SCIENCES, INC. 2024-08-29 — — US disclosed
CN-113227089-B Substituted 6-azabenzimidazole compounds as HPK1 inhibitors 吉利德科学公司 2024-07-05 — — CN disclosed
EP-4371987-A1 SUBSTITUTED 6-AZABENZIMIDAZOLE COMPOUNDS AS HPK1 INHIBITORS Gilead Sciences, Inc. (US) 2024-05-22 — — EP disclosed
US-11897878-B2 Substituted 6-azabenzimidazole compounds GILEAD SCIENCES, INC. (US) 2024-02-13 — — US disclosed
EP-3873903-B1 SUBSTITUTED 6-AZABENZIMIDAZOLE COMPOUNDS AS HPK1 INHIBITORS GILEAD SCIENCES INC (US) 2024-01-24 — — EP disclosed
EP-3873903-B1 SUBSTITUTED 6-AZABENZIMIDAZOLE COMPOUNDS AS HPK1 INHIBITORS GILEAD SCIENCES INC (US) 2024-01-24 — — EP disclosed
US-20220213091-A1 SUBSTITUTED 6-AZABENZIMIDAZOLE COMPOUNDS GILEAD SCIENCES, INC. 2022-07-07 — — US disclosed
US-20220213091-A1 SUBSTITUTED 6-AZABENZIMIDAZOLE COMPOUNDS GILEAD SCIENCES, INC. 2022-07-07 — — US disclosed
US-11203591-B2 Substituted 6-azabenzimidazole compounds GILEAD SCIENCES, INC. (US) 2021-12-21 — — US disclosed
US-11203591-B2 Substituted 6-azabenzimidazole compounds GILEAD SCIENCES, INC. (US) 2021-12-21 — — US disclosed
EP-3873903-A1 SUBSTITUTED 6-AZABENZIMIDAZOLE COMPOUNDS AS HPK1 INHIBITORS GILEAD SCIENCES, INC. (US) 2021-09-08 — — EP disclosed
CN-113227089-A Substituted 6-azabenzimidazole compounds as HPK1 inhibitors 吉利德科学公司 2021-08-06 — — CN disclosed
US-20210115037-A1 SUBSTITUTED 6-AZABENZIMIDAZOLE COMPOUNDS GILEAD SCIENCES, INC. 2021-04-22 — — US disclosed
US-20210115037-A1 SUBSTITUTED 6-AZABENZIMIDAZOLE COMPOUNDS GILEAD SCIENCES, INC. 2021-04-22 — — US disclosed
US-5017211-A Herbicides CIBA-GEIGY CORPORATION (US) 1991-05-21 — — US disclosed
EP-0333791-A1 HETEROCYCLIC COMPOUNDS CIBA-GEIGY AG (CH) 1989-09-27 — — EP disclosed
WO-1989002891-A1 HETEROCYCLIC COMPOUNDS F. HOFFMANN-LA ROCHE & CO. AKTIENGESELLSCHAFT (CH) 1989-04-06 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240287061-A1 SUBSTITUTED 6-AZABENZIMIDAZOLE COMPOUNDS CDK6, HIPK1, DCK SMN1; SMN2 4077/4885HPGD 539/4885MAPT 3509/4885
US-12258346-B2 Substituted 6-azabenzimidazole compounds CDK6, HIPK1, DCK SMN1; SMN2 4077/4885HPGD 539/4885MAPT 3509/4885
US-20210115037-A1 SUBSTITUTED 6-AZABENZIMIDAZOLE COMPOUNDS CDK6, HIPK1, DCK SMN1; SMN2 4077/4885HPGD 539/4885MAPT 3509/4885
US-11203591-B2 Substituted 6-azabenzimidazole compounds CDK6, HIPK1, DCK SMN1; SMN2 4077/4885HPGD 539/4885MAPT 3509/4885
US-20220213091-A1 SUBSTITUTED 6-AZABENZIMIDAZOLE COMPOUNDS CDK6, HIPK1, DCK SMN1; SMN2 4077/4885HPGD 539/4885MAPT 3509/4885
US-11897878-B2 Substituted 6-azabenzimidazole compounds CDK6, HIPK1, DCK SMN1; SMN2 4077/4885HPGD 539/4885MAPT 3509/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.