Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIP4K2A | P48426 | 1/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.35 |
| ▸ | METTL3 | Q86U44 | 1/20 | 0.34 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
| ▸ | HTR6 | P50406 | 5/20 | 0.33 |
| ▸ | PRMT5 | O14744 | 4/20 | 0.33 |
| ▸ | WDR77 | Q9BQA1 | 3/20 | 0.33 |
| ▸ | LCK | P06239 | 1/20 | 0.33 |
| ▸ | SRC | P12931 | 1/20 | 0.33 |
| ▸ | TEK | Q02763 | 1/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.33 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.32 |
| ▸ | ACACB | O00763 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12596590 | 0.87 | PIP4K2A (0.42) | PIP4K2AMETTL3HTR6PRMT5WDR77 | |
| Tert-Butyl Formate SCHEMBL28057856 | 0.87 | METTL3 (0.46) | METTL3PRMT5WDR77LCKSRC | |
| Tert-Butyl Formate SCHEMBL27651256 | 0.81 | CYP3A4 (0.39) | — | |
| Tert-Butyl Formate SCHEMBL27864305 | 0.80 | ADK (0.42) | LCKSRCTEK | |
| SCHEMBL16967987 | 0.78 | PIP4K2A (0.49) | PIP4K2APRMT5WDR77SRCSLC22A12 | |
| SCHEMBL24753099 | 0.75 | PIP4K2A (0.44) | PIP4K2APRMT5WDR77SRCSLC22A12 | |
| SCHEMBL1939828 | 0.75 | PIP4K2A (0.44) | PIP4K2APRMT5WDR77LCKSRC | |
| SCHEMBL515111 | 0.75 | GPR119 (0.57) | GPR119SRC | |
| Ethoxycarbonyl Group SCHEMBL28826851 | 0.74 | METTL3 (0.45) | METTL3PRMT5WDR77LCKSRC | |
| SCHEMBL17877686 | 0.74 | PIP4K2A (0.44) | PIP4K2APRMT5WDR77LCKSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105431436-A | Pyrrolo [2,3-D ] pyrimidine derivatives, processes for their preparation and their use as kinase inhibitors | NERVIANO MEDICAL SCIENCES SRL | 2016-03-23 | — | — | CN | disclosed |
| CN-1726218-A | Pyrrolopyrimidine derivatives | PFIZER PROD INC (US) | 2006-01-25 | — | — | CN | disclosed |