Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 1/20 | 0.57 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | PLK1 | P53350 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | TNF | P01375 | 3/20 | 0.47 |
| ▸ | HTR6 | P50406 | 10/20 | 0.45 |
| ▸ | TNFSF11 | O14788 | 2/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | HTR7 | P34969 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL946621 | 0.86 | LMNA (0.71) | AKR1C3AKR1C1LMNASMN1; SMN2PLK1 | |
| SCHEMBL27622290 | 0.85 | LMNA (0.72) | AKR1C3AKR1C1LMNASMN1; SMN2PLK1 | |
| SCHEMBL20424529 | 0.79 | AKR1C3 (0.64) | AKR1C3AKR1C1LMNASMN1; SMN2PLK1 | |
| SCHEMBL950467 | 0.78 | AKR1C3 (0.50) | AKR1C3AKR1C1LMNASMN1; SMN2PLK1 | |
| SCHEMBL950466 | 0.78 | AKR1C3 (0.50) | AKR1C3AKR1C1LMNASMN1; SMN2PLK1 | |
| SCHEMBL21274665 | 0.78 | AKR1C3 (0.56) | AKR1C3AKR1C1LMNASMN1; SMN2PLK1 | |
| SCHEMBL946389 | 0.78 | HTR6 (0.56) | AKR1C3AKR1C1LMNASMN1; SMN2HTR6 | |
| SCHEMBL19194701 | 0.77 | LMNA (0.71) | AKR1C3AKR1C1LMNASMN1; SMN2PLK1 | |
| SCHEMBL3029070 | 0.76 | PPARG (0.62) | AKR1C3AKR1C1HTR6HTR7 | |
| SCHEMBL1466474 | 0.76 | AKR1C3 (0.60) | AKR1C3AKR1C1LMNASMN1; SMN2PLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1720225-B | N-arylsulfonyl-3-substituted indoles having 5-hydroxytryptamine receptor affinity, process for their preparation and pharmaceutical compositions containing them | SUVEN LIFE SCIENCES LTD | 2011-05-18 | — | — | CN | disclosed |
| CN-101544592-A | N-arylsulfonyl-3-substituted indoles having serotonin receptor affinity, process for their preparation and pharmaceutical composition containing them | SUVEN LIFE SCIENCES LTD (IN) | 2009-09-30 | — | — | CN | disclosed |
| CN-1720225-A | N-arylsulfonyl-3-substituted indoles having 5-hydroxytryptamine receptor affinity, process for their preparation and pharmaceutical compositions containing them | SUVEN LIFE SCIENCES LTD (IN) | 2006-01-11 | — | — | CN | disclosed |