Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.60 |
| ▸ | PARK7 | Q99497 | 1/20 | 0.57 |
| ▸ | CHRM5 | P08912 | 4/20 | 0.51 |
| ▸ | CA12 | O43570 | 1/20 | 0.48 |
| ▸ | CA1 | P00915 | 1/20 | 0.48 |
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
| ▸ | CA9 | Q16790 | 1/20 | 0.48 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.45 |
| ▸ | CASP3 | P42574 | 3/20 | 0.44 |
| ▸ | CASP7 | P55210 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3028471 | 0.83 | OPRM1 (0.53) | POLBPARK7CHRM5OPRM1ALDH1A1 | |
| SCHEMBL6559542 | 0.81 | PARK7 (0.64) | POLBPARK7CHRM5CA12CA1 | |
| SCHEMBL4624984 | 0.80 | PARK7 (0.63) | POLBPARK7CHRM5CA12CA1 | |
| SCHEMBL17274922 | 0.78 | PARK7 (0.69) | POLBPARK7CHRM5CA12CA1 | |
| SCHEMBL29349059 | 0.78 | ACHE (0.60) | PARK7CHRM5ALDH1A1ALDH3A1CASP3 | |
| SCHEMBL13196466 | 0.78 | CUL4A (0.43) | PARK7OPRM1ALDH1A1ALDH3A1CASP3 | |
| SCHEMBL29011254 | 0.77 | PARK7 (0.67) | POLBPARK7CHRM5CA12CA1 | |
| SCHEMBL31440735 | 0.76 | PARK7 (0.59) | POLBPARK7CHRM5CA12CA1 | |
| SCHEMBL11798678 | 0.76 | PARK7 (0.62) | POLBPARK7CHRM5CA12CA1 | |
| SCHEMBL11150416 | 0.75 | PARK7 (0.64) | POLBPARK7CHRM5CA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010090680-A1 | SUBSTITUTED OXINDOLE CB2 AGONISTS | WYETH LLC (US) | 2010-08-12 | — | — | WO | disclosed |
| WO-2010090680-A1 | SUBSTITUTED OXINDOLE CB2 AGONISTS | WYETH LLC (US) | 2010-08-12 | — | — | WO | disclosed |