Known targets — ChEMBL curated mechanism
GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BM
The experimentally established mechanism targets of Amantadine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2D known ✓ | O15399 | 4/20 | 0.54 |
| ▸ | GRIN3B known ✓ | O60391 | 4/20 | 0.54 |
| ▸ | GRIN1 known ✓ | Q05586 | 4/20 | 0.54 |
| ▸ | GRIN2A known ✓ | Q12879 | 4/20 | 0.54 |
| ▸ | GRIN2B known ✓ | Q13224 | 4/20 | 0.54 |
| ▸ | GRIN2C known ✓ | Q14957 | 4/20 | 0.54 |
| ▸ | GRIN3A known ✓ | Q8TCU5 | 4/20 | 0.54 |
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | TSHR | P16473 | 2/20 | 0.54 |
| ▸ | SLC22A1 | O15245 | 2/20 | 0.54 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.54 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.54 |
| ▸ | STAT6 | P42226 | 1/20 | 0.54 |
| ▸ | SLC47A1 | Q96FL8 | 1/20 | 0.54 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.54 |
| ▸ | THRB | P10828 | 2/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | BLM | P54132 | 1/20 | 0.52 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Amantadine SCHEMBL27677379 | 0.82 | THRB (0.68) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| SCHEMBL14917397 | 0.80 | TDP1 (0.46) | TSHRTHRBCYP2C9SMN1; SMN2TDP1 | |
| Amantadine SCHEMBL15015750 | 0.80 | THRB (0.71) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| Amantadine SCHEMBL20771731 | 0.78 | GRIN1 (0.59) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| Amantadine SCHEMBL15015696 | 0.78 | LMNA (0.70) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| Amantadine SCHEMBL4339906 | 0.77 | THRB (0.74) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| Amantadine SCHEMBL4602828 | 0.77 | GRIN1 (0.81) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| Amantadine SCHEMBL15016083 | 0.76 | LMNA (0.67) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| Amantadine SCHEMBL16109305 | 0.74 | LMNA (0.82) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| Amantadine SCHEMBL29011286 | 0.74 | GRIN1 (0.87) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1713787-A | Organic electroluminescent device, method for producing the same, and electronic apparatus | SEIKO EPSON CORP (JP) | 2005-12-28 | — | — | CN | disclosed |