Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.71 |
| ▸ | MEN1 | O00255 | 1/20 | 0.71 |
| ▸ | POLB | P06746 | 1/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.71 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.69 |
| ▸ | NPC1 | O15118 | 2/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.65 |
| ▸ | HPGD | P15428 | 1/20 | 0.65 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.65 |
| ▸ | PPARG | P37231 | 1/20 | 0.62 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.62 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.62 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.62 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.61 |
| ▸ | FEN1 | P39748 | 1/20 | 0.61 |
| ▸ | HSD17B1 | P14061 | 6/20 | 0.59 |
| ▸ | HSD17B2 | P37059 | 6/20 | 0.59 |
| ▸ | HPGDS | O60760 | 2/20 | 0.58 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12494820 | 0.90 | HSD17B1 (0.66) | RAB9AMEN1POLBKMT2AHDAC1 | |
| SCHEMBL1761545 | 0.87 | RAB9A (0.92) | RAB9AMEN1POLBKMT2AHDAC1 | |
| SCHEMBL10275320 | 0.85 | RAB9A (0.69) | RAB9AMEN1POLBKMT2AHDAC1 | |
| SCHEMBL11913196 | 0.84 | HSD17B1 (0.81) | RAB9AMEN1POLBKMT2AHDAC1 | |
| SCHEMBL11913209 | 0.84 | HSD17B1 (0.57) | RAB9AMEN1POLBKMT2AHDAC1 | |
| SCHEMBL3097763 | 0.83 | RAB9A (0.67) | RAB9AMEN1POLBKMT2AHDAC1 | |
| SCHEMBL2690201 | 0.83 | IKBKB (0.68) | RAB9AMEN1POLBKMT2AHDAC1 | |
| SCHEMBL4128733 | 0.83 | RAB9A (0.67) | RAB9AMEN1POLBKMT2AHDAC1 | |
| SCHEMBL2491267 | 0.83 | RAB9A (1.00) | RAB9AMEN1POLBKMT2AHDAC1 | |
| SCHEMBL11913205 | 0.82 | HSD17B1 (0.57) | RAB9AMEN1POLBKMT2AHDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100343256-C | Biaryl substituted diazabicycloalkane amides as nicotinic acetylcholine agonists | ASTRAZENECA AB (SE) | 2007-10-17 | — | — | CN | claimed |
| CN-1678615-A | Biaryl substituted diazabicycloalkanes as nicotinic acetylcholine antagonists | ASTRAZENECA AB (SE) | 2005-10-05 | — | — | CN | claimed |
| CN-104109155-A | Novel compounds | TANABE SEIYAKU CO | 2014-10-22 | — | — | CN | disclosed |
| CN-103819465-A | Novel compound | MITSUBISHI TANABE PHARMA CORP | 2014-05-28 | — | — | CN | disclosed |
| CN-102850324-A | Indole compounds | MICROBIA INC | 2013-01-02 | — | — | CN | disclosed |
| CN-101563337-A | Indole compounds | MICROBIA INC (US) | 2009-10-21 | — | — | CN | disclosed |
| CN-100343256-C | Biaryl substituted diazabicycloalkane amides as nicotinic acetylcholine agonists | ASTRAZENECA AB (SE) | 2007-10-17 | — | — | CN | disclosed |
| CN-1678615-A | Biaryl substituted diazabicycloalkanes as nicotinic acetylcholine antagonists | ASTRAZENECA AB (SE) | 2005-10-05 | — | — | CN | disclosed |