Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.51 |
| ▸ | JAK2 | O60674 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | PDE5A | O76074 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | CPS1 | P31327 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 4/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2762664 | 0.90 | MAPK1 (0.62) | MAPK1KMT2AMEN1HIF1ACYP2D6 | |
| Hydrochloric Acid SCHEMBL2763425 | 0.89 | MAPK1 (0.60) | MAPK1KMT2AMEN1HIF1ACYP2D6 | |
| SCHEMBL2762044 | 0.85 | MAPK1 (0.55) | MAPK1HIF1ACYP2D6KDM4EPDE5A | |
| Trifluoroacetic Acid SCHEMBL2762337 | 0.85 | MAPK1 (0.56) | MAPK1KMT2AMEN1HIF1ACYP2D6 | |
| SCHEMBL8324482 | 0.81 | HPGD (0.63) | MAPK1KMT2AMEN1LMNAHTT | |
| SCHEMBL2762440 | 0.80 | HTT (0.52) | MAPK1KMT2AMEN1HTTKDM4E | |
| SCHEMBL2762036 | 0.80 | HTR1A (0.57) | CYP2D6ALDH1A1CYP2C9CYP2C19USP2 | |
| SCHEMBL2761934 | 0.78 | GABRD (0.60) | CYP2D6KDM4E | |
| SCHEMBL11951819 | 0.76 | KDM4E (0.40) | MAPK1KMT2AMEN1CYP2D6JAK2 | |
| SCHEMBL16134867 | 0.76 | POLB (0.70) | MAPK1KMT2ALMNAHTTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8268853-B2 | 3,9-diazaspiro[5,5]undecane amides and ureas and methods of use thereof | ABBOTT LABORATORIES (US) | 2012-09-18 | — | — | US | claimed |
| US-20100331353-A1 | 3,9-DIAZASPIRO[5,5]UNDECANE AMIDES AND UREAS AND METHODS OF USE THEREOF | ABBOTT LABORATORIES (US) | 2010-12-30 | — | — | US | claimed |
| WO-2010151815-A2 | 3,9-DIAZASPIRO[5,5]UNDECANE AMIDES AND UREAS AND METHODS OF USE THEREOF | ABBOTT LABORATORIES (US) | 2010-12-29 | — | — | WO | claimed |
| US-8268853-B2 | 3,9-diazaspiro[5,5]undecane amides and ureas and methods of use thereof | ABBOTT LABORATORIES (US) | 2012-09-18 | — | — | US | disclosed |
| US-20100331353-A1 | 3,9-DIAZASPIRO[5,5]UNDECANE AMIDES AND UREAS AND METHODS OF USE THEREOF | ABBOTT LABORATORIES (US) | 2010-12-30 | — | — | US | disclosed |
| WO-2010151815-A2 | 3,9-DIAZASPIRO[5,5]UNDECANE AMIDES AND UREAS AND METHODS OF USE THEREOF | ABBOTT LABORATORIES (US) | 2010-12-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100331353-A1 | 3,9-DIAZASPIRO[5,5]UNDECANE AMIDES AND UREAS AND METHODS OF USE THEREOF | CHRNA9, CHRNE, CHRNA2 | MAPK1 3195/4885KMT2A 3308/4885MEN1 4472/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.