Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.39 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.39 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.36 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.36 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.36 |
| ▸ | CACNB1 | Q02641 | 1/20 | 0.36 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27607821 | 0.84 | ESR2 (0.42) | SMN1; SMN2TDP1 | |
| SCHEMBL510474 | 0.79 | SRC (0.44) | SMN1; SMN2MEN1KMT2ATAS1R3TAS1R1 | |
| SCHEMBL27549905 | 0.78 | ESR1 (0.41) | MEN1KMT2AALDH1A1LMNAMAPT | |
| SCHEMBL28017567 | 0.77 | HTR1A (0.40) | SMN1; SMN2MEN1KMT2AALDH1A1TP53 | |
| SCHEMBL6207353 | 0.76 | SRC (0.46) | SMN1; SMN2MEN1KMT2ATAS1R3TAS1R1 | |
| SCHEMBL16672638 | 0.76 | SMN1; SMN2 (0.49) | SMN1; SMN2MEN1KMT2ATAS1R3TAS1R1 | |
| SCHEMBL2687513 | 0.75 | TAS1R3 (0.49) | SMN1; SMN2MEN1KMT2ATAS1R3TAS1R1 | |
| SCHEMBL3382824 | 0.74 | SRC (0.43) | SMN1; SMN2MEN1KMT2ACACNA1GCACNA2D1 | |
| SCHEMBL16672839 | 0.73 | SMN1; SMN2 (0.46) | SMN1; SMN2MEN1KMT2ATAS1R3TAS1R1 | |
| SCHEMBL5156728 | 0.73 | PDE5A (0.41) | SMN1; SMN2MEN1KMT2AALDH1A1CACNA1G |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101611005-A | Be used as the acetophenones of the replacement of PDE4 inhibitor | LEO PHARMA AS (DK) | 2009-12-23 | — | — | CN | disclosed |
| CN-100381429-C | Thiazole derivatives | HOFFMANN LA ROCHE (CH) | 2008-04-16 | — | — | CN | disclosed |
| CN-1946703-A | Substituted thiazole and pyrimidine derivatives as melanocortin receptor modulators | TRANSTECH PHARMA INC (US) | 2007-04-11 | — | — | CN | disclosed |
| CN-1675188-A | Thiazole derivatives | HOFFMANN LA ROCHE (CH) | 2005-09-28 | — | — | CN | disclosed |