Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 2/20 | 0.49 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 4/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | CCR1 | P32246 | 1/20 | 0.43 |
| ▸ | CCR5 | P51681 | 1/20 | 0.43 |
| ▸ | CCR8 | P51685 | 1/20 | 0.43 |
| ▸ | METAP1 | P53582 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | DOHH | Q9BU89 | 1/20 | 0.43 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.43 |
| ▸ | HPGDS | O60760 | 3/20 | 0.41 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10040945 | 0.90 | KDM4E (0.48) | TGFBR1NPY5RNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL154508 | 0.88 | TGFBR1 (0.56) | TGFBR1PIM1PIM2 | |
| SCHEMBL29504110 | 0.88 | TGFBR1 (0.56) | TGFBR1PIM1PIM2 | |
| SCHEMBL8113038 | 0.88 | SMN1; SMN2 (0.46) | TGFBR1NPY5RNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL3463943 | 0.87 | KDM4E (0.48) | NPC1RAB9ASMN1; SMN2LRRK2KDM4E | |
| SCHEMBL8489109 | 0.87 | L3MBTL1 (0.44) | TGFBR1NPY5RSMN1; SMN2LRRK2KDM4E | |
| SCHEMBL5490810 | 0.87 | TGFBR1 (0.54) | TGFBR1NPY5RLRRK2KDM4ELMNA | |
| SCHEMBL28756497 | 0.84 | LRRK2 (0.37) | TGFBR1NPY5RNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL29074720 | 0.81 | CHEK2 (0.55) | TGFBR1LRRK2KDM4ECYP1A2KDR | |
| SCHEMBL218119 | 0.81 | ALOX15 (0.52) | NPC1RAB9ASMN1; SMN2KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1770980-A | Pyrazoles and methods of making and using the same | BIOGEN IDEC INC (US) | 2006-05-10 | — | — | CN | claimed |