Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piperazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | PDE4A | P27815 | 1/20 | 0.50 |
| ▸ | KDR | P35968 | 1/20 | 0.50 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Piperazine SCHEMBL3937304 | 1.00 | HIF1A (0.50) | HIF1AMAPTPDE4AKDRCXCR4 | |
| Piperazine SCHEMBL16008573 | 0.85 | HIF1A (0.43) | HIF1AMAPTPDE4AKDRCXCR4 | |
| Pyrrolidine SCHEMBL16636111 | 0.85 | ALDH1A1 (0.53) | HIF1AMAPTPDE4AKDRCXCR4 | |
| Piperazine SCHEMBL5700791 | 0.85 | HIF1A (0.43) | HIF1AMAPTPDE4AKDRCXCR4 | |
| Piperazine SCHEMBL29088716 | 0.85 | HIF1A (0.43) | HIF1AMAPTPDE4AKDRCXCR4 | |
| Phosphoramidic Acid SCHEMBL5035761 | 0.80 | — | — | |
| Phosphoramidic Acid SCHEMBL5035760 | 0.80 | HIF1A (0.36) | HIF1AMAPTPDE4AKDR | |
| Thiomorpholine SCHEMBL28541335 | 0.77 | — | — | |
| Piperazine SCHEMBL23235242 | 0.75 | HIF1A (0.50) | HIF1AMAPTPDE4AKDRCXCR4 | |
| Piperazine SCHEMBL5053500 | 0.75 | HIF1A (0.50) | HIF1AMAPTPDE4AKDRCXCR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101410643-A | Torque limiter | JTEKT CORP (JP) | 2009-04-15 | — | — | CN | disclosed |
| CN-1809383-A | Recombinant IL-9 antibodies and uses thereof | MEDIMMUNE INC (US) | 2006-07-26 | — | — | CN | disclosed |