Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piperazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | PDE4A | P27815 | 1/20 | 0.50 |
| ▸ | KDR | P35968 | 1/20 | 0.50 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Piperazine SCHEMBL27628485 | 1.00 | HIF1A (0.50) | HIF1AMAPTPDE4AKDRCXCR4 | |
| Piperazine SCHEMBL16008573 | 0.85 | HIF1A (0.43) | HIF1AMAPTPDE4AKDRCXCR4 | |
| Pyrrolidine SCHEMBL16636111 | 0.85 | ALDH1A1 (0.53) | HIF1AMAPTPDE4AKDRCXCR4 | |
| Piperazine SCHEMBL5700791 | 0.85 | HIF1A (0.43) | HIF1AMAPTPDE4AKDRCXCR4 | |
| Piperazine SCHEMBL29088716 | 0.85 | HIF1A (0.43) | HIF1AMAPTPDE4AKDRCXCR4 | |
| Phosphoramidic Acid SCHEMBL5035761 | 0.80 | — | — | |
| Phosphoramidic Acid SCHEMBL5035760 | 0.80 | HIF1A (0.36) | HIF1AMAPTPDE4AKDR | |
| Thiomorpholine SCHEMBL28541335 | 0.77 | — | — | |
| Piperazine SCHEMBL23235242 | 0.75 | HIF1A (0.50) | HIF1AMAPTPDE4AKDRCXCR4 | |
| Piperazine SCHEMBL5053500 | 0.75 | HIF1A (0.50) | HIF1AMAPTPDE4AKDRCXCR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1349890-B1 | FLAME RETARDANT POLYESTER COMPOSITIONS | SABIC INNOVATIVE PLASTICS IP (NL) | 2008-10-15 | — | — | EP | claimed |
| EP-1425340-A2 | FLAME-RETARDANT POLYESTER COMPOSITION, METHOD FOR THE PREPARATION THEREOF, AND ARTICLES DERIVED THEREFROM | GENERAL ELECTRIC COMPANY (US) | 2004-06-09 | — | — | EP | claimed |
| US-6737455-B2 | FOR USE IN AUTOMOTIVE PARTS TO ELECTRIC AND ELECTRONIC APPLIANCES | GENERAL ELECTRIC COMPANY | 2004-05-18 | — | — | US | claimed |
| US-6710108-B2 | MIXTURE OF POLYESTER AND ORGANONITROGEN AND ORGANOPHOSPHOROUS COMPOUNDS; ELECTRONICS | GENERAL ELECTRIC COMPANY | 2004-03-23 | — | — | US | claimed |
| EP-1349890-A1 | FLAME RETARDANT POLYESTER COMPOSITIONS | GENERAL ELECTRIC COMPANY (US) | 2003-10-08 | — | — | EP | claimed |
| US-20030073763-A1 | Flame-retardant polyester composition, method for the preparation thereof, and articles derived therefrom | SABIC GLOBAL TECHNOLOGIES B.V. (NL) | 2003-04-17 | — | — | US | claimed |
| WO-2003018680-A2 | FLAME-RETARDANT POLYESTER COMPOSITION, METHOD FOR THE PREPARATION THEREOF, AND ARTICLES DERIVED THEREFROM | GENERAL ELECTRIC COMPANY (US) | 2003-03-06 | — | — | WO | claimed |
| US-20030022969-A1 | Flame retardant polyester compositions | SABIC GLOBAL TECHNOLOGIES B.V. (NL) | 2003-01-30 | — | — | US | claimed |
| US-20020111403-A1 | Flame retardant polyester compositions | GENERAL ELECTRIC COMPANY | 2002-08-15 | — | — | US | claimed |
| WO-2002057352-A1 | FLAME RETARDANT POLYESTER COMPOSITIONS | GENERAL ELECTRIC COMPANY (US) | 2002-07-25 | — | — | WO | claimed |
| EP-1425340-B1 | FLAME-RETARDANT POLYESTER COMPOSITION, METHOD FOR THE PREPARATION THEREOF, AND ARTICLES DERIVED THEREFROM | SABIC INNOVATIVE PLASTICS IP (NL) | 2009-04-08 | — | — | EP | disclosed |
| EP-1349890-B1 | FLAME RETARDANT POLYESTER COMPOSITIONS | SABIC INNOVATIVE PLASTICS IP (NL) | 2008-10-15 | — | — | EP | disclosed |
| US-7056973-B2 | High flow polyphenylene ether formulations | GENERAL ELECTRIC (US) | 2006-06-06 | — | — | US | disclosed |
| EP-1274800-B1 | HIGH FLOW POLYPHENYLENE ETHER FORMULATIONS | GEN ELECTRIC (US) | 2006-02-08 | — | — | EP | disclosed |
| EP-1276813-B1 | FLAME RETARDANT POLYESTER COMPOSITIONS | GEN ELECTRIC (US) | 2005-06-01 | — | — | EP | disclosed |
| US-20020111403-A1 | Flame retardant polyester compositions | GENERAL ELECTRIC COMPANY | 2002-08-15 | — | — | US | disclosed |
| WO-2002057352-A1 | FLAME RETARDANT POLYESTER COMPOSITIONS | GENERAL ELECTRIC COMPANY (US) | 2002-07-25 | — | — | WO | disclosed |
| WO-2001081470-A1 | FLAME RETARDANT POLYESTER COMPOSITIONS | GENERAL ELECTRIC COMPANY (US) | 2001-11-01 | — | — | WO | disclosed |
| WO-2001079351-A1 | HIGH FLOW POLYPHENYLENE ETHER FORMULATIONS | GENERAL ELECTRIC COMPANY (US) | 2001-10-25 | — | — | WO | disclosed |
| WO-2000012608-A1 | FLAME RESISTANT POLYKETONE RESIN COMPOSITIONS | GENERAL ELECTRIC COMPANY (US) | 2000-03-09 | — | — | WO | disclosed |