Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.48 |
| ▸ | THRB | P10828 | 3/20 | 0.46 |
| ▸ | MMP13 | P45452 | 3/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4255014 | 0.90 | SMN1; SMN2 (0.51) | SMN1; SMN2ALDH1A1LMNAHTTTDP1 | |
| SCHEMBL4265054 | 0.81 | SMN1; SMN2 (0.69) | SMN1; SMN2ALDH1A1LMNAHTTTDP1 | |
| SCHEMBL27628806 | 0.81 | SMN1; SMN2 (0.47) | SMN1; SMN2ALDH1A1LMNAHTTTDP1 | |
| SCHEMBL4266405 | 0.69 | MMP13 (0.70) | SMN1; SMN2ALDH1A1LMNAHTTTDP1 | |
| SCHEMBL4262512 | 0.68 | HDAC6 (0.44) | SMN1; SMN2ALDH1A1LMNAHTTTDP1 | |
| SCHEMBL4260422 | 0.68 | MMP13 (0.68) | SMN1; SMN2ALDH1A1LMNAHTTTDP1 | |
| SCHEMBL4263436 | 0.68 | MMP13 (0.78) | SMN1; SMN2ALDH1A1LMNAHTTTDP1 | |
| SCHEMBL4263261 | 0.67 | SMN1; SMN2 (0.47) | SMN1; SMN2ALDH1A1LMNAHTTTDP1 | |
| SCHEMBL5512243 | 0.67 | MAPK1 (0.46) | SMN1; SMN2ALDH1A1LMNARAB9ANPC1 | |
| SCHEMBL4262856 | 0.67 | MMP13 (0.71) | SMN1; SMN2ALDH1A1LMNAHTTTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100379415-C | Hetero biaryl derivatives as matrix metalloproteinase inhibitors | WARNER LAMBERT CO (US) | 2008-04-09 | — | — | CN | disclosed |
| CN-1674892-A | Hetero biaryl derivatives as matrix metalloproteinase inhibitors | WARNER LAMBERT CO (US) | 2005-09-28 | — | — | CN | disclosed |