Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.69 |
| ▸ | RAB9A | P51151 | 4/20 | 0.69 |
| ▸ | NPC1 | O15118 | 3/20 | 0.69 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.66 |
| ▸ | MMP13 | P45452 | 10/20 | 0.58 |
| ▸ | CASP3 | P42574 | 1/20 | 0.56 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4255014 | 0.83 | SMN1; SMN2 (0.51) | SMN1; SMN2RAB9ANPC1HDAC6MMP13 | |
| SCHEMBL4256694 | 0.82 | SMN1; SMN2 (0.68) | SMN1; SMN2RAB9ANPC1HDAC6MMP13 | |
| SCHEMBL27628808 | 0.81 | SMN1; SMN2 (0.49) | SMN1; SMN2RAB9ANPC1HDAC6MMP13 | |
| SCHEMBL4256535 | 0.81 | RAB9A (0.67) | SMN1; SMN2RAB9ANPC1HDAC6MMP13 | |
| SCHEMBL30395910 | 0.80 | HDAC6 (1.00) | SMN1; SMN2RAB9ANPC1HDAC6MMP13 | |
| SCHEMBL20535167 | 0.80 | HDAC6 (1.00) | SMN1; SMN2RAB9ANPC1HDAC6MMP13 | |
| SCHEMBL4262326 | 0.78 | SMN1; SMN2 (0.66) | SMN1; SMN2RAB9ANPC1HDAC6MMP13 | |
| SCHEMBL14589086 | 0.78 | SMN1; SMN2 (0.63) | SMN1; SMN2RAB9ANPC1HDAC6MMP13 | |
| SCHEMBL14589085 | 0.78 | SMN1; SMN2 (0.63) | SMN1; SMN2RAB9ANPC1HDAC6MMP13 | |
| SCHEMBL8849222 | 0.78 | HDAC6 (0.60) | SMN1; SMN2RAB9ANPC1HDAC6MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090029995-A1 | HETERO BIARYL DERIVATIVES AS MATRIX METALLOPROTEINASE INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2009-01-29 | — | — | US | disclosed |
| CN-100379415-C | Hetero biaryl derivatives as matrix metalloproteinase inhibitors | WARNER LAMBERT CO (US) | 2008-04-09 | — | — | CN | disclosed |
| US-7179822-B2 | Hetero biaryl derivatives as matrix metalloproteinase inhibitors | WARNER-LAMBERT COMPANY (US) | 2007-02-20 | — | — | US | disclosed |
| EP-1680125-A1 | COMBINATION OF AN ALLOSTERIC INHIBITOR OF MATRIX METALLOPROTEINASE-13 AND A LIGAND TO AN ALPHA-2-DELTA RECEPTOR | Warner-Lambert Company LLC (US) | 2006-07-19 | — | — | EP | disclosed |
| CN-1674892-A | Hetero biaryl derivatives as matrix metalloproteinase inhibitors | WARNER LAMBERT CO (US) | 2005-09-28 | — | — | CN | disclosed |
| EP-1536784-A1 | HETERO BIARYL DERIVATIVES AS MATRIX METALLOPROTEINASE INHIBITORS | WARNER-LAMBERT COMPANY LLC (US) | 2005-06-08 | — | — | EP | disclosed |
| WO-2005002585-A1 | COMBINATION OF AN ALLOSTERIC INHIBITOR OF MATRIX METALLOPROTEINASE-13 AND A LIGAND TO AN ALPHA-2-DELTA RECEPTOR | WARNER-LAMBERT COMPANY LLC (US) | 2005-01-13 | — | — | WO | disclosed |
| US-20050004177-A1 | Combination of an allosteric inhibitor of matrix metalloproteinase-13 and a ligand to an alpha-2-delta receptor | WARNER-LAMBERT COMPANY LLC | 2005-01-06 | — | — | US | disclosed |
| US-20040048863-A1 | Hetero biaryl derivatives as matrix metalloproteinase inhibitors | WARNER-LAMBERT COMPANY LLC | 2004-03-11 | — | — | US | disclosed |
| WO-2004014366-A1 | HETERO BIARYL DERIVATIVES AS MATRIX METALLOPROTEINASE INHIBITORS | WARNER-LAMBERT COMPANY LLC (US) | 2004-02-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090029995-A1 | HETERO BIARYL DERIVATIVES AS MATRIX METALLOPROTEINASE INHIBITORS | MMP9, MMP2, MMP3 | SMN1; SMN2 2194/4885RAB9A 919/4885NPC1 1536/4885 |
| US-20050004177-A1 | Combination of an allosteric inhibitor of matrix metalloproteinase-13 and a ligand to an alpha-2-delta receptor | MMP13, MMP10, MMP11 | SMN1; SMN2 1184/4885RAB9A 3127/4885NPC1 3853/4885 |
| US-20040048863-A1 | Hetero biaryl derivatives as matrix metalloproteinase inhibitors | MMP13, MMP11, MMP9 | SMN1; SMN2 1617/4885RAB9A 413/4885NPC1 1391/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.