Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.45 |
| ▸ | HPGD | P15428 | 10/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.45 |
| ▸ | MAPT | P10636 | 9/20 | 0.45 |
| ▸ | GAA | P10253 | 9/20 | 0.45 |
| ▸ | PKM | P14618 | 8/20 | 0.45 |
| ▸ | MEN1 | O00255 | 7/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.45 |
| ▸ | GLA | P06280 | 6/20 | 0.45 |
| ▸ | ALOX12 | P18054 | 5/20 | 0.45 |
| ▸ | CASP1 | P29466 | 4/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.45 |
| ▸ | CASP7 | P55210 | 3/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2762972 | 0.82 | ALDH1A1 (0.49) | ALDH1A1HPGDKDM4EMAPTGAA | |
| SCHEMBL930995 | 0.79 | ALDH1A1 (0.53) | ALDH1A1HPGDKDM4EMAPTGAA | |
| SCHEMBL928465 | 0.78 | ADORA2A (0.46) | ALDH1A1HPGDKDM4EMAPTGAA | |
| SCHEMBL929564 | 0.77 | ALDH1A1 (0.45) | ALDH1A1HPGDKDM4EMAPTGAA | |
| SCHEMBL2762948 | 0.77 | ALDH1A1 (0.45) | ALDH1A1HPGDKDM4EMAPTGAA | |
| SCHEMBL2762872 | 0.73 | ADORA2A (0.59) | ALDH1A1HPGDKDM4EMAPTPKM | |
| SCHEMBL25083932 | 0.64 | MAPT (0.47) | ALDH1A1HPGDKDM4EMAPTGAA | |
| SCHEMBL15935028 | 0.64 | MYC (0.43) | ALDH1A1HPGDKDM4EMAPTGAA | |
| SCHEMBL13680700 | 0.62 | MAP4K4 (0.41) | ALDH1A1HPGDKDM4EMAPTGAA | |
| SCHEMBL13681286 | 0.62 | ALDH1A1 (0.41) | ALDH1A1HPGDKDM4EMAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1722798-B1 | PYRIMIDINE COMPOUNDS AS PURINE RECEPTOR ANTAGONISTS | VERNALIS R&D LTD (GB) | 2010-10-20 | — | — | EP | disclosed |
| US-20080182860-A1 | Pyrimidine Compounds as Purine Receptor Antagonist | VERNALIS (R&D) LTD. (GB) | 2008-07-31 | — | — | US | disclosed |
| EP-1722798-A1 | PYRIMIDINE COMPOUNDS AS PURINE RECEPTOR ANTAGONIST | VERNALIS (R&D) LTD (GB) | 2006-11-22 | — | — | EP | disclosed |
| WO-2005079800-A1 | PYRIMIDINE COMPOUNDS AS PURINE RECEPTOR ANTAGONIST | VERNALIS (R & D) LTD. (GB) | 2005-09-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080182860-A1 | Pyrimidine Compounds as Purine Receptor Antagonist | ADORA3, P2RY10, ADORA2A | ALDH1A1 1455/4885HPGD 3498/4885KDM4E 4731/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.