Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.40 |
| ▸ | GAA | P10253 | 5/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | HTT | P42858 | 3/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | MITF | O75030 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | PPP1CA | P62136 | 1/20 | 0.36 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.36 |
| ▸ | RELA | Q04206 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3667467 | 0.83 | GRM5 (0.42) | LMNAMAPTGRIA1GRIA3PDE4D | |
| SCHEMBL6686817 | 0.82 | ADORA3 (0.36) | PTGS2SMN1; SMN2LMNAMAPT | |
| SCHEMBL6680865 | 0.80 | TRPV1 (0.46) | SMN1; SMN2LMNACNR1F10POLB | |
| SCHEMBL18074830 | 0.79 | GRM5 (0.37) | KMT2AHTTNPSR1LMNAMAPT | |
| SCHEMBL6674834 | 0.75 | CYP2A6 (0.57) | SMN1; SMN2MAPTTP53GRM5 | |
| SCHEMBL3665776 | 0.75 | GRM5 (0.48) | GRIA1GRIA3PDE4DGRM5KDM5B | |
| SCHEMBL3672898 | 0.75 | PDE4D (0.38) | MAPTBRD4GRIA1GRIA3PDE4D | |
| SCHEMBL3667343 | 0.75 | GRM5 (0.47) | SMN1; SMN2MAPTGRIA1GRIA3PDE4D | |
| SCHEMBL6679872 | 0.74 | PTGS1 (0.40) | PTGS2KMT2AMAPTMEN1KDM5B | |
| SCHEMBL3666593 | 0.74 | GRM5 (0.38) | GRIA1GRIA3PDE4DGRM5KDM5B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2177520-A1 | 1,5-Di(aryl or heteroaryl)-3-halo-2(1H)-pyridones as intermediates for the preparation of AMPA receptor inhibitors | Eisai R&D Management Co., Ltd. (JP) | 2010-04-21 | — | — | EP | disclosed |