Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 5/20 | 0.62 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.50 |
| ▸ | GFER | P55789 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.50 |
| ▸ | CDC7 | O00311 | 1/20 | 0.48 |
| ▸ | PIK3CG | P48736 | 6/20 | 0.48 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.48 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.48 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.48 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.48 |
| ▸ | PDXK | O00764 | 1/20 | 0.48 |
| ▸ | GAK | O14976 | 1/20 | 0.48 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.48 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.48 |
| ▸ | PIP5K1C | O60331 | 1/20 | 0.48 |
| ▸ | STK16 | O75716 | 1/20 | 0.48 |
| ▸ | PIK3C2G | O75747 | 1/20 | 0.48 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.48 |
| ▸ | OXSR1 | O95747 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24309649 | 0.80 | ADORA1 (0.63) | ADORA1ADORA2ACDC7 | |
| SCHEMBL30129635 | 0.78 | HSD17B1 (0.47) | ADORA1PIK3CGABL1FLT3HSD17B1 | |
| SCHEMBL30129595 | 0.78 | RXFP1 (0.44) | ADORA1PIK3CGHSD17B1HSD17B2 | |
| SCHEMBL1116418 | 0.76 | PIK3CG (0.60) | ADORA1ADORA2AADORA2BPIK3CGPIK3CA | |
| SCHEMBL4355012 | 0.76 | PIK3CG (0.63) | ADORA1ADORA2AGFERKMT2AADORA2B | |
| SCHEMBL27631647 | 0.75 | PIK3CG (0.45) | ADORA1ADORA2AGFERKMT2AADORA2B | |
| SCHEMBL1116404 | 0.74 | ADORA1 (0.70) | ADORA1ADORA2AGFERKMT2APIK3CG | |
| SCHEMBL1585912 | 0.73 | PIK3CG (0.51) | ADORA1ADORA2AADORA2BPIK3CGPIK3CA | |
| SCHEMBL27631427 | 0.73 | SYK (0.74) | BRAF | |
| SCHEMBL12575968 | 0.72 | SRC (0.61) | ADORA1PIK3CGPIK3CAPIK3CBPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1678321-A | Methods of treating or preventing autoimmune diseases with 2, 4-pyrimidinediamine compounds | RIGEL PHARMACEUTICALS INC (US) | 2005-10-05 | — | — | CN | disclosed |