Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 13/20 | 0.60 |
| ▸ | CCR3 | P51677 | 13/20 | 0.60 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.50 |
| ▸ | OXTR | P30559 | 1/20 | 0.41 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.40 |
| ▸ | CCR5 | P51681 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4969392 | 0.86 | HRH1 (0.56) | HRH1CCR3KCNH2SLC6A4OPRM1 | |
| SCHEMBL5383787 | 0.83 | HTR1A (0.51) | HRH1SLC6A4 | |
| SCHEMBL180455 | 0.77 | HRH1 (0.59) | HRH1CCR3KCNH2 | |
| SCHEMBL12193462 | 0.77 | IKBKB (0.56) | HRH1CCR3 | |
| SCHEMBL8261147 | 0.76 | HTR2C (0.49) | HRH1CCR3OXTRAVPR1A | |
| SCHEMBL4969419 | 0.76 | CCR3 (0.55) | HRH1CCR3KCNH2 | |
| SCHEMBL24783476 | 0.76 | OXTR (0.46) | HRH1CCR3OXTRAVPR1ASLC6A4 | |
| SCHEMBL5193030 | 0.76 | HRH1 (0.55) | HRH1CCR3KCNH2 | |
| SCHEMBL18841143 | 0.76 | HRH1 (1.00) | HRH1CCR3KCNH2 | |
| SCHEMBL4674817 | 0.76 | HRH1 (0.61) | HRH1CCR3KCNH2OXTRAVPR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1684952-A | Novel piperidine derivatives for use in the treatment of chemokine mediated disease states | ASTRAZENECA AB (SE) | 2005-10-19 | — | — | CN | disclosed |