Known targets — ChEMBL curated mechanism
GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHMGCRMMP1MMP13MMP7MMP8PTGS1PTGS2ileSpolrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Nervonic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 known ✓ | P23219 | 1/20 | 0.66 |
| ▸ | FABP3 | P05413 | 9/20 | 0.96 |
| ▸ | TERT | O14746 | 3/20 | 0.66 |
| ▸ | MAPT | P10636 | 2/20 | 0.66 |
| ▸ | BLM | P54132 | 2/20 | 0.66 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.66 |
| ▸ | FABP4 | P15090 | 2/20 | 0.66 |
| ▸ | GMNN | O75496 | 1/20 | 0.66 |
| ▸ | USP2 | O75604 | 1/20 | 0.66 |
| ▸ | LMNA | P02545 | 1/20 | 0.66 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.66 |
| ▸ | POLB | P06746 | 1/20 | 0.66 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.66 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.66 |
| ▸ | APEX1 | P27695 | 1/20 | 0.66 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.66 |
| ▸ | RECQL | P46063 | 1/20 | 0.66 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.66 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.66 |
| ▸ | MMP2 | P08253 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Vaccenic Acid SCHEMBL15452907 | 1.00 | FABP3 (0.96) | FABP3TERTMAPTBLMHSD17B10 | |
| Oleic Acid SCHEMBL11324221 | 1.00 | FABP3 (0.96) | FABP3TERTMAPTBLMHSD17B10 | |
| Oleic Acid SCHEMBL28219314 | 1.00 | FABP3 (0.96) | FABP3TERTMAPTBLMHSD17B10 | |
| Palmitoleic Acid SCHEMBL4920826 | 1.00 | FABP3 (0.96) | FABP3TERTMAPTBLMHSD17B10 | |
| Oleic Acid SCHEMBL29196 | 1.00 | FABP3 (0.96) | FABP3TERTMAPTBLMHSD17B10 | |
| Erucic Acid SCHEMBL31135511 | 1.00 | FABP3 (0.96) | FABP3TERTMAPTBLMHSD17B10 | |
| Oleic Acid SCHEMBL29193 | 1.00 | FABP3 (0.96) | FABP3TERTMAPTBLMHSD17B10 | |
| Oleic Acid SCHEMBL28385238 | 0.98 | FABP3 (0.92) | FABP3TERTMAPTBLMHSD17B10 | |
| Oleic Acid SCHEMBL1203413 | 0.98 | FABP3 (0.92) | FABP3TERTMAPTBLMHSD17B10 | |
| Oleic Acid SCHEMBL28478796 | 0.98 | FABP3 (0.92) | FABP3TERTMAPTBLMHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116059449-B | Double-layer degradable bone tissue engineering scaffold for treating bone defect and preparation method thereof | 山东大学齐鲁医院 | 2023-11-03 | — | — | CN | claimed |
| CN-116059449-A | Double-layer degradable bone tissue engineering scaffold for treating bone defect and preparation method thereof | 山东大学齐鲁医院 | 2023-05-05 | — | — | CN | claimed |
| CN-115350322-B | Preparation method of calcium nervonate nanoparticles and application of calcium nervonate nanoparticles in preparation of bone defect repair material | 山东大学 | 2023-03-07 | — | — | CN | claimed |
| CN-115350322-A | Preparation method of calcium nervonate nanoparticles and application of calcium nervonate nanoparticles in preparation of bone defect repair material | 山东大学 | 2022-11-18 | — | — | CN | claimed |
| CN-114773150-A | Method for extracting nervonic acid from allium sativum seed kernel oil by water extraction, alcohol precipitation and calcification and application of nervonic acid | 云南华年生物科技有限公司 | 2022-07-22 | — | — | CN | claimed |
| CN-109805390-A | A kind of calcium nervonate, nervonic acid zinc and vitamin K2Compound composition soft capsule | 云南大学 | 2019-05-28 | — | — | CN | claimed |
| CN-101991564-A | Production process for separating, extracting and purifying bioactive substance calcium nervonate and application thereof to treatment of Alzheimer's disease | HANGZHOU SWEETANT BIOTECH CO LTD | 2011-03-30 | — | — | CN | claimed |
| CN-1775733-A | Calcium nervonate and its preparing method and use | UNIV YUNNAN (CN) | 2006-05-24 | — | — | CN | claimed |
| CN-116059449-B | Double-layer degradable bone tissue engineering scaffold for treating bone defect and preparation method thereof | 山东大学齐鲁医院 | 2023-11-03 | — | — | CN | disclosed |
| CN-116059449-B | Double-layer degradable bone tissue engineering scaffold for treating bone defect and preparation method thereof | 山东大学齐鲁医院 | 2023-11-03 | — | — | CN | disclosed |
| CN-116262034-A | In-vivo two-photon microscopic imaging system | 深圳先进技术研究院 | 2023-06-16 | — | — | CN | disclosed |
| CN-116059449-A | Double-layer degradable bone tissue engineering scaffold for treating bone defect and preparation method thereof | 山东大学齐鲁医院 | 2023-05-05 | — | — | CN | disclosed |
| CN-116059449-A | Double-layer degradable bone tissue engineering scaffold for treating bone defect and preparation method thereof | 山东大学齐鲁医院 | 2023-05-05 | — | — | CN | disclosed |
| CN-115350322-B | Preparation method of calcium nervonate nanoparticles and application of calcium nervonate nanoparticles in preparation of bone defect repair material | 山东大学 | 2023-03-07 | — | — | CN | disclosed |
| CN-103396304-A | Nervonic acid chemosynthesis method | KUNMING GOODKWANG HEALTH CARE FOOD CO LTD | 2013-11-20 | — | — | CN | disclosed |
| CN-101991564-A | Production process for separating, extracting and purifying bioactive substance calcium nervonate and application thereof to treatment of Alzheimer's disease | HANGZHOU SWEETANT BIOTECH CO LTD | 2011-03-30 | — | — | CN | disclosed |
| CN-101991564-A | Production process for separating, extracting and purifying bioactive substance calcium nervonate and application thereof to treatment of Alzheimer's disease | HANGZHOU SWEETANT BIOTECH CO LTD | 2011-03-30 | — | — | CN | disclosed |
| CN-101991564-A | Production process for separating, extracting and purifying bioactive substance calcium nervonate and application thereof to treatment of Alzheimer's disease | HANGZHOU SWEETANT BIOTECH CO LTD | 2011-03-30 | — | — | CN | disclosed |
| CN-1775733-A | Calcium nervonate and its preparing method and use | UNIV YUNNAN (CN) | 2006-05-24 | — | — | CN | disclosed |
| CN-1775733-A | Calcium nervonate and its preparing method and use | UNIV YUNNAN (CN) | 2006-05-24 | — | — | CN | disclosed |