Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 1/20 | 0.48 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.48 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.45 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.45 |
| ▸ | DHODH | Q02127 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL662652 | 0.85 | KDM4E (0.64) | AKR1C3AKR1C2AKR1C1KDM4ESMN1; SMN2 | |
| SCHEMBL30172583 | 0.85 | KDM4E (0.64) | AKR1C3AKR1C2AKR1C1KDM4ESMN1; SMN2 | |
| SCHEMBL28267403 | 0.84 | KDM4E (0.62) | AKR1C3AKR1C2AKR1C1KDM4ESMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL11329279 | 0.84 | KDM4E (0.62) | AKR1C3AKR1C2AKR1C1KDM4ESMN1; SMN2 | |
| SCHEMBL7328160 | 0.82 | AKR1C3 (0.48) | AKR1C3AKR1C2AKR1C1KDM4ESMN1; SMN2 | |
| SCHEMBL10202038 | 0.82 | NPC1 (0.49) | AKR1C3AKR1C2AKR1C1KDM4ESMN1; SMN2 | |
| SCHEMBL5202032 | 0.82 | NCOA1 (0.65) | AKR1C3AKR1C2AKR1C1KDM4ESMN1; SMN2 | |
| SCHEMBL28540684 | 0.78 | KDM4E (0.50) | AKR1C3AKR1C2AKR1C1KDM4ESMN1; SMN2 | |
| SCHEMBL663977 | 0.78 | KDM4E (0.70) | KDM4ESMN1; SMN2LMNAPOLBMEN1 | |
| SCHEMBL1308656 | 0.73 | KMT2A (0.77) | KDM4ESMN1; SMN2LMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101475528-A | Novel quinoline, tetrahydroquinazoline, and pyrimidine derivatives and methods of treatment related to the use thereof | TAISHO PHARMACEUTICAL CO LTD (JP) | 2009-07-08 | — | — | CN | disclosed |
| CN-100451004-C | Pyrimidine derivatives | ARENA PHARM INC (JP) | 2009-01-14 | — | — | CN | disclosed |
| CN-1798736-A | Novel quinoline, tetrahydroquinazoline and pyrimidine derivatives and methods of treatment related to their use | ARENA PHARM INC (JP) | 2006-07-05 | — | — | CN | disclosed |