Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.44 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.44 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.44 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.42 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15237488 | 0.85 | KDM4E (0.49) | KDM4ELMNATP53RXFP1SMN1; SMN2 | |
| SCHEMBL28536559 | 0.84 | L3MBTL1 (0.60) | KDM4ELMNASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL28535854 | 0.83 | KDM4E (0.64) | KDM4EKMT2AMEN1NPC1RAB9A | |
| SCHEMBL28046850 | 0.83 | ALOX15 (0.55) | KDM4ELMNATP53RXFP1SMN1; SMN2 | |
| SCHEMBL10202038 | 0.81 | NPC1 (0.49) | KDM4ELMNATP53SMN1; SMN2KMT2A | |
| SCHEMBL28540687 | 0.81 | KDM4E (0.58) | KDM4ELMNATP53RXFP1SMN1; SMN2 | |
| SCHEMBL30172583 | 0.81 | KDM4E (0.64) | KDM4ELMNATP53RXFP1SMN1; SMN2 | |
| SCHEMBL662652 | 0.81 | KDM4E (0.64) | KDM4ELMNATP53RXFP1SMN1; SMN2 | |
| SCHEMBL28530337 | 0.80 | KDM4E (0.53) | KDM4ELMNASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL28267403 | 0.80 | KDM4E (0.62) | KDM4ELMNATP53RXFP1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109467549-B | Quinoline-substituted chalcone compound, preparation method and application thereof | 中国药科大学 | 2021-02-09 | — | — | CN | disclosed |