Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.42 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | LIPA | P38571 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | S1PR5 | Q9H228 | 3/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL679005 | 1.00 | MAPT (0.44) | MAPTAPOBEC3AAPOBEC3GHTTSMN1; SMN2 | |
| Bicarbonate SCHEMBL35810 | 1.00 | MAPT (0.44) | MAPTAPOBEC3AAPOBEC3GHTTSMN1; SMN2 | |
| SCHEMBL2719576 | 0.91 | MAPT (0.41) | MAPTAPOBEC3AAPOBEC3GHTTSMN1; SMN2 | |
| SCHEMBL21476541 | 0.91 | MAPT (0.41) | MAPTAPOBEC3AAPOBEC3GHTTSMN1; SMN2 | |
| Bicarbonate SCHEMBL851219 | 0.84 | MAPT (0.45) | MAPTAPOBEC3AAPOBEC3GHTTSMN1; SMN2 | |
| Bicarbonate SCHEMBL2696873 | 0.84 | MAPT (0.45) | MAPTAPOBEC3AAPOBEC3GHTTSMN1; SMN2 | |
| Bicarbonate SCHEMBL28052024 | 0.82 | MAPT (0.47) | MAPTAPOBEC3AAPOBEC3GHTTSMN1; SMN2 | |
| SCHEMBL28199763 | 0.78 | MAPT (0.51) | MAPTAPOBEC3AAPOBEC3GHTTSMN1; SMN2 | |
| SCHEMBL2380073 | 0.77 | MAPT (0.50) | MAPTAPOBEC3AAPOBEC3GHTTSMN1; SMN2 | |
| SCHEMBL22733771 | 0.76 | MAPT (0.53) | MAPTAPOBEC3AAPOBEC3GHTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2177935-A1 | SAFETY AND PREVENTION HELMET VISOR HAVING A SURFACE THAT HAS BEEN TREATED TO PROVIDE EYE PROTECTION AND THERAPY | Universidad Complutense De Madrid (ES) | 2010-04-21 | — | — | EP | disclosed |
| US-7524060-B2 | Therapeutic contact lens for pseudo-aphakic eyes and/or eyes with retinal neuro-degeneration | UNIVERSIDAD COMPLUTENSE DE MADRID (ES) | 2009-04-28 | — | — | US | disclosed |
| US-20090046244-A1 | SAFETY HELMET VISOR WITH A TREATED SURFACE FOR EYE PROTECTION AND THERAPY | UNIVERSIDAD COMPLUTENSE DE MADRID | 2009-02-19 | — | — | US | disclosed |
| US-20060238703-A1 | Therapeutic contact lens for pseudo-aphakic eyes and/or eyes with retinal neuro-degeneration | UNIVERSIDAD COMPLUTENSE DE MADRID | 2006-10-26 | — | — | US | disclosed |