Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.42 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | LIPA | P38571 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | S1PR5 | Q9H228 | 3/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL2763274 | 1.00 | MAPT (0.44) | MAPTAPOBEC3AAPOBEC3GHTTSMN1; SMN2 | |
| Bicarbonate SCHEMBL35810 | 1.00 | MAPT (0.44) | MAPTAPOBEC3AAPOBEC3GHTTSMN1; SMN2 | |
| SCHEMBL2719576 | 0.91 | MAPT (0.41) | MAPTAPOBEC3AAPOBEC3GHTTSMN1; SMN2 | |
| SCHEMBL21476541 | 0.91 | MAPT (0.41) | MAPTAPOBEC3AAPOBEC3GHTTSMN1; SMN2 | |
| Bicarbonate SCHEMBL851219 | 0.84 | MAPT (0.45) | MAPTAPOBEC3AAPOBEC3GHTTSMN1; SMN2 | |
| Bicarbonate SCHEMBL2696873 | 0.84 | MAPT (0.45) | MAPTAPOBEC3AAPOBEC3GHTTSMN1; SMN2 | |
| Bicarbonate SCHEMBL28052024 | 0.82 | MAPT (0.47) | MAPTAPOBEC3AAPOBEC3GHTTSMN1; SMN2 | |
| SCHEMBL28199763 | 0.78 | MAPT (0.51) | MAPTAPOBEC3AAPOBEC3GHTTSMN1; SMN2 | |
| SCHEMBL2380073 | 0.77 | MAPT (0.50) | MAPTAPOBEC3AAPOBEC3GHTTSMN1; SMN2 | |
| SCHEMBL22733771 | 0.76 | MAPT (0.53) | MAPTAPOBEC3AAPOBEC3GHTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 730 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115003413-B | Process for preparing double metal cyanide catalysts | 科思创德国股份有限公司 | 2024-02-27 | — | — | CN | claimed |
| CN-114874483-B | PMI foam material and preparation method and application thereof | 湖南博翔新材料有限公司 | 2023-08-29 | — | — | CN | claimed |
| CN-116462791-A | Multifunctional polymethacrylimide foam material and preparation method and application thereof | 湖南博翔新材料有限公司 | 2023-07-21 | — | — | CN | claimed |
| CN-116120694-A | Thermal expansion microsphere with core-shell structure and preparation method thereof | 万华化学集团股份有限公司 | 2023-05-16 | — | — | CN | claimed |
| CN-116096764-A | Functionalized polymers | 赢创运营有限公司 | 2023-05-09 | — | — | CN | claimed |
| CN-115003413-A | Process for preparing double metal cyanide catalysts | 科思创德国股份有限公司 | 2022-09-02 | — | — | CN | claimed |
| CN-114874483-A | PMI foam material and preparation method and application thereof | 湖南博翔新材料有限公司 | 2022-08-09 | — | — | CN | claimed |
| CN-110100333-B | Electrode for all-solid-state battery and method for manufacturing same | 株式会社LG新能源 | 2022-07-22 | — | — | CN | claimed |
| CN-110734525-B | Fluorine-containing cage type silsesquioxane modified polychlorotrifluoroethylene resin | 浙江省化工研究院有限公司 | 2022-07-01 | — | — | CN | claimed |
| CN-114407442-A | Low-friction-coefficient silicon core pipe and preparation method thereof | 浙江邦德管业有限公司 | 2022-04-29 | — | — | CN | claimed |
| CN-110964226-A | Anti-yellowing expandable microsphere and preparation method thereof | 快思瑞科技(上海)有限公司 | 2020-04-07 | — | — | CN | claimed |
| CN-110734525-A | fluorine-containing cage type silsesquioxane modified polychlorotrifluoroethylene resin | 浙江省化工研究院有限公司 | 2020-01-31 | — | — | CN | claimed |
| CN-110392705-A | Composition useful as a pressure sensitive adhesive, use thereof and adhesive articles comprising the same | 意大利艾坚蒙树脂有限公司 | 2019-10-29 | — | — | CN | claimed |
| CN-104937027-B | Underfill composition and the packaging technology for using the composition | 汉高知识产权控股有限责任公司 | 2018-10-12 | — | — | CN | claimed |
| CN-102149761-B | Low temperature curing compositions | 汉高知识产权控股有限责任公司 | 2016-10-12 | — | — | CN | claimed |
| CN-104937027-A | Underfill composition and packaging process using the same | Henkel IP & Holding GmbH | 2015-09-23 | — | — | CN | claimed |
| EP-2276513-A2 | INTERVERTEBRAL DISC AND INTRAOCULAR LENS | Aston University (GB) | 2011-01-26 | — | — | EP | claimed |
| US-20100063193-A1 | Process for manufacturing outdoor artificial stone boards with methacrylate resin by means of the vibro-compression under vacuum system | Cosentino , S.A. (ES) | 2010-03-11 | — | — | US | claimed |
| WO-2009127844-A2 | INTERVERTEBRAL DISC AND INTRAOCULAR LENS | ASTON UNIVERSITY (GB) | 2009-10-22 | — | — | WO | claimed |
| WO-2004090002-A1 | LIQUID COMPOSITION POLYMERIZABLE INTO ORGANIC GLASS HAVING GOOD OPTICAL AND PHYSICO-MECHANICAL CHARACTERISTICS | GREAT LAKES CHEMICAL (EUROPE) GMBH (CH) | 2004-10-21 | — | — | WO | claimed |