Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TPMT | P51580 | 1/20 | 0.41 |
| ▸ | CA5A | P35218 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.37 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 3/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | STAT3 | P40763 | 1/20 | 0.34 |
| ▸ | STAT1 | P42224 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.34 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7266611 | 0.87 | TPMT (0.54) | TPMTHCAR1RAB9ATDP1NPC1 | |
| SCHEMBL2624954 | 0.84 | TPMT (0.55) | TPMTCA5APKMCYP2A6HCAR1 | |
| SCHEMBL6175987 | 0.83 | TPMT (0.64) | TPMTCA5AHCAR1LMNAKMT2A | |
| SCHEMBL910082 | 0.82 | TPMT (0.40) | TPMTHCAR1LMNAKMT2ARAB9A | |
| SCHEMBL95695 | 0.79 | TPMT (0.62) | TPMTCA5APKMCYP2A6HCAR1 | |
| SCHEMBL9753152 | 0.79 | HCAR1 (0.61) | TPMTCA5AHCAR1KMT2ARAB9A | |
| SCHEMBL11325769 | 0.78 | TPMT (0.40) | TPMTHCAR1LMNAKMT2ARAB9A | |
| SCHEMBL9033776 | 0.78 | TSHR (0.48) | TPMTHCAR1KMT2ATDP1MAPT | |
| SCHEMBL12020867 | 0.77 | TPMT (0.43) | TPMTCA5APKMCYP2A6HCAR1 | |
| SCHEMBL14541116 | 0.76 | MLYCD (0.45) | LMNAKMT2ARAB9ATDP1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100430389-C | Inhibition of phosphoinositide 3-kinase beta | KINACIA PTY LTD (SE) | 2008-11-05 | — | — | CN | disclosed |
| CN-101260104-A | Inhibition of phosphoinositide 3-kinase beta | ASTRAZENECA AB (SE) | 2008-09-10 | — | — | CN | disclosed |
| CN-1688575-A | INHIBITION OF PHOSPHOINOSITIDE 3-KINASE BETA | KINACIA PTY LTD (AU) | 2005-10-26 | — | — | CN | disclosed |