Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 9/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5900070 | 0.89 | BRD4 (0.46) | BRD4HTTALDH1A1MAPTMAPK1 | |
| SCHEMBL28759673 | 0.83 | CHRNB2 (0.42) | BRD4ALDH1A1MAPTTDP1MEN1 | |
| SCHEMBL27655058 | 0.82 | BRD4 (0.40) | BRD4HTTALDH1A1MAPTPOLB | |
| SCHEMBL28759664 | 0.81 | BRD4 (0.38) | BRD4MEN1KMT2A | |
| SCHEMBL27633724 | 0.81 | ITGB1 (0.44) | BRD4HTTALDH1A1MEN1KMT2A | |
| SCHEMBL27634118 | 0.80 | CHRNB2 (0.38) | BRD4ALDH1A1POLBMEN1KMT2A | |
| SCHEMBL27633759 | 0.80 | ALDH1A1 (0.37) | BRD4ALDH1A1MAPT | |
| SCHEMBL28757419 | 0.79 | RAB9A (0.41) | BRD4ALDH1A1MAPK1RAB9AMEN1 | |
| SCHEMBL27654934 | 0.79 | ALDH1A1 (0.41) | BRD4HTTALDH1A1MAPTMAPK1 | |
| SCHEMBL27654931 | 0.79 | KMT2A (0.38) | BRD4ALDH1A1MAPTNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1795177-A | 1, 2, 4-substituted 1, 2, 3, 4-tetrahydro-and 1, 2 dihydro-quinolines and 1, 2, 3, 4-tetrahydro-quinoxaline derivatives as CETP inhibitors for the treatment of atherosclerosis and obesity | PFIZER PROD INC (US) | 2006-06-28 | — | — | CN | disclosed |