Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.38 |
| ▸ | ESR1 | P03372 | 2/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 2/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.36 |
| ▸ | FYN | P06241 | 1/20 | 0.36 |
| ▸ | CSF1R | P07333 | 1/20 | 0.36 |
| ▸ | RET | P07949 | 1/20 | 0.36 |
| ▸ | IGF1R | P08069 | 1/20 | 0.36 |
| ▸ | MET | P08581 | 1/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4635152 | 0.84 | PTPN1 (0.45) | PTPN1HIF1AESR1RECQLKMT2A | |
| SCHEMBL27634761 | 0.82 | PTPN1 (0.44) | PTPN1HIF1AESR1RECQLKMT2A | |
| SCHEMBL16507220 | 0.82 | PTPN1 (0.42) | PTPN1HIF1ASMN1; SMN2CHEK1AURKA | |
| SCHEMBL27395153 | 0.79 | KMT2A (0.43) | HIF1AESR1RECQLKMT2ASMN1; SMN2 | |
| SCHEMBL4795365 | 0.78 | ESR1 (0.42) | PTPN1HIF1AESR1RECQLKMT2A | |
| SCHEMBL9082172 | 0.73 | PTPN1 (0.39) | PTPN1HIF1ASMN1; SMN2ACHECHEK1 | |
| SCHEMBL6863654 | 0.72 | PTPN1 (0.47) | PTPN1CHEK1AURKADAPK3JAK2 | |
| SCHEMBL8435546 | 0.72 | ALOX15 (0.55) | HIF1AESR1RECQLKMT2ASMN1; SMN2 | |
| SCHEMBL27688209 | 0.72 | KMT2A (0.48) | PTPN1RECQLKMT2ASMN1; SMN2ALOX15 | |
| SCHEMBL31621484 | 0.72 | ELANE (0.46) | HIF1AESR1RECQLKMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100567242-C | Hsp90 family protein blockers | KYOWA HAKKO KOGYO KK (JP) | 2009-12-09 | — | — | CN | disclosed |
| CN-1791568-A | Hsp90 family protein inhibitors | KYOWA HAKKO KOGYO KK (JP) | 2006-06-21 | — | — | CN | disclosed |