Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMO | O15229 | 2/20 | 0.43 |
| ▸ | ATR | Q13535 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 4/20 | 0.39 |
| ▸ | RAB9A | P51151 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | CTRC | Q99895 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | ALPL | P05186 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | XDH | P47989 | 1/20 | 0.36 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | RUNX1 | Q01196 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27634968 | 0.83 | KMO (0.47) | KMOATRNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL4680329 | 0.80 | CDH1 (0.43) | KMONPC1CTRCKDM4EALDH1A1 | |
| SCHEMBL27655897 | 0.79 | KMO (0.43) | KMOATRNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL11216316 | 0.78 | ATR (0.53) | KMOATRNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL27634863 | 0.77 | SMN1; SMN2 (0.47) | KMOATRNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL27655888 | 0.75 | HPGD (0.47) | NPC1RAB9ASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL27656038 | 0.74 | ATR (0.41) | KMOATRNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL27634965 | 0.74 | KMO (0.39) | KMOATRNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL27655941 | 0.73 | KMT2A (0.46) | NPC1RAB9APARP1KMT2AMEN1 | |
| SCHEMBL27655896 | 0.73 | ALDH1A1 (0.40) | KMOATRNPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1809554-A | 3-substituted 5,6-diaryl-pyrazine-2-carboxamide and -2-sulfonamide derivatives as cb1 modulators | ASTRAZENECA AB (SE) | 2006-07-26 | — | — | CN | disclosed |