Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 3/20 | 0.52 |
| ▸ | CCR5 | P51681 | 3/20 | 0.52 |
| ▸ | CCR8 | P51685 | 3/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.38 |
| ▸ | COPS5 | Q92905 | 1/20 | 0.38 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.36 |
| ▸ | NOS3 | P29474 | 2/20 | 0.34 |
| ▸ | NOS2 | P35228 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | NCK1 | P16333 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
| ▸ | NOS1 | P29475 | 1/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28777985 | 0.79 | NOS1 (0.39) | CYP2A6NOS1AURKASMN1; SMN2 | |
| SCHEMBL29751072 | 0.79 | NOS1 (0.39) | CYP2A6NOS1AURKASMN1; SMN2 | |
| SCHEMBL12696174 | 0.79 | CCR1 (0.56) | CCR1CCR5CCR8CYP1A2KDM4E | |
| SCHEMBL23360456 | 0.76 | SMN1; SMN2 (0.38) | CYP2A6ALDH1A1BACE1NOS1AURKA | |
| SCHEMBL29862595 | 0.76 | SMN1; SMN2 (0.38) | CYP2A6ALDH1A1BACE1NOS1AURKA | |
| SCHEMBL19001715 | 0.76 | CCR1 (0.52) | CCR1CCR5CCR8CYP1A2KDM4E | |
| SCHEMBL12232242 | 0.76 | CCR1 (0.52) | CCR1CCR5CCR8CYP1A2KDM4E | |
| SCHEMBL27940876 | 0.76 | KDM4E (0.44) | KDM4EAURKA | |
| SCHEMBL25322668 | 0.76 | RAB9A (0.40) | CYP1A2CYP2A6ALDH1A1SMN1; SMN2 | |
| SCHEMBL31010906 | 0.76 | RAB9A (0.40) | CYP1A2CYP2A6ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113620946-B | Preparation method of 2-chloro-1, 8-naphthyridine derivatives | 山东明化新材料有限公司 | 2022-06-21 | — | — | CN | claimed |
| CN-100422181-C | [1,8] naphthyridin-2-ones and related compounds for the treatment of schizophrenia | WARNER LAMBERT CO (US) | 2008-10-01 | — | — | CN | disclosed |
| CN-1839134-A | [1,8]naphthyridin-2-ones and related compounds for the treatment of schizophrenia | WARNER LAMBERT CO (US) | 2006-09-27 | — | — | CN | disclosed |