SCHEMBL28777985

SCHEMBL28777985

Clc1cnc2nc(Cl)ccc2c1

nearest known ligand 0.39

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
NOS1 P29475 2/20 0.39
DYRK1A Q13627 1/20 0.39
HTT P42858 1/20 0.38
HSD17B10 Q99714 1/20 0.38
GUSB P08236 3/20 0.36
AURKA O14965 1/20 0.35
KIF11 P52732 1/20 0.35
LMNA P02545 1/20 0.34
CYP2C9 P11712 1/20 0.34
TSHR P16473 1/20 0.34
APEX1 P27695 1/20 0.34
SMN1; SMN2 Q16637 1/20 0.34
NPC1 O15118 1/20 0.33
CYP2A6 P11509 1/20 0.33
FGFR1 P11362 1/20 0.33
PIK3CD O00329 1/20 0.32
NR4A2 P43354 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29751072 1.00 NOS1 (0.39) NOS1DYRK1AHTTHSD17B10GUSB
SCHEMBL23360456 0.79 SMN1; SMN2 (0.38) NOS1DYRK1AHTTAURKASMN1; SMN2
SCHEMBL29862595 0.79 SMN1; SMN2 (0.38) NOS1DYRK1AHTTAURKASMN1; SMN2
SCHEMBL27635367 0.79 CCR1 (0.52) NOS1AURKASMN1; SMN2CYP2A6
SCHEMBL21114788 0.79 NOS1 (0.37) NOS1DYRK1AHTTHSD17B10GUSB
SCHEMBL31505370 0.75 PARP1 (0.38)
SCHEMBL31010906 0.75 RAB9A (0.40) CYP2C9SMN1; SMN2NPC1CYP2A6
SCHEMBL31505373 0.75 PARP1 (0.38)
SCHEMBL25322668 0.75 RAB9A (0.40) CYP2C9SMN1; SMN2NPC1CYP2A6
SCHEMBL27940876 0.75 KDM4E (0.44) AURKAKIF11NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114685351-B OLED main body material based on triptycene framework and preparation method and application thereof 中国科学院化学研究所 2023-04-18 CN disclosed
CN-114685351-A OLED main body material based on triptycene framework and preparation method and application thereof 中国科学院化学研究所 2022-07-01 CN disclosed