Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 | Q01959 | 13/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 9/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 9/20 | 0.44 |
| ▸ | GCK | P35557 | 4/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.42 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27467646 | 0.81 | KCNH2 (0.46) | SLC6A3SLC6A2SLC6A4GCKKCNH2 | |
| SCHEMBL27502236 | 0.81 | KCNH2 (0.46) | SLC6A3SLC6A2SLC6A4GCKKCNH2 | |
| SCHEMBL27616381 | 0.81 | KCNH2 (0.45) | SLC6A3SLC6A2SLC6A4GCKKCNH2 | |
| SCHEMBL27465661 | 0.71 | KCNH2 (0.43) | SLC6A3SLC6A2SLC6A4GCKKCNH2 | |
| SCHEMBL27558086 | 0.71 | GCK (0.44) | SLC6A3SLC6A2SLC6A4GCKKCNH2 | |
| SCHEMBL12917669 | 0.70 | GCK (0.52) | SLC6A3SLC6A2SLC6A4GCKKCNH2 | |
| SCHEMBL1171463 | 0.69 | KCNH2 (0.63) | GCKKCNH2 | |
| SCHEMBL1445384 | 0.69 | KCNH2 (0.63) | SLC6A3GCKKCNH2 | |
| SCHEMBL1445381 | 0.69 | KCNH2 (0.63) | SLC6A3GCKKCNH2 | |
| SCHEMBL1171465 | 0.69 | KCNH2 (0.63) | GCKKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100469770-C | 5-substituted-pyrazine or -pyridine glucokinase activators | HOFFMANN LA ROCHE (CH) | 2009-03-18 | — | — | CN | disclosed |
| CN-1726197-A | 5-substituted-pyrazine or -pyridine glucokinase activators | HOFFMANN LA ROCHE (CH) | 2006-01-25 | — | — | CN | disclosed |