Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.46 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.45 |
| ▸ | GCK | P35557 | 4/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | PTGDR | Q13258 | 6/20 | 0.41 |
| ▸ | TBXA2R | P21731 | 3/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | PDE2A | O00408 | 2/20 | 0.38 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.38 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27502236 | 1.00 | KCNH2 (0.46) | KCNH2FFAR1GCKSLC6A3SLC6A2 | |
| SCHEMBL27558086 | 0.90 | GCK (0.44) | KCNH2FFAR1GCKSLC6A3SLC6A2 | |
| SCHEMBL27616381 | 0.89 | KCNH2 (0.45) | KCNH2GCKSLC6A3SLC6A2SLC6A4 | |
| SCHEMBL27765336 | 0.87 | GCK (0.42) | KCNH2FFAR1GCKSLC6A3SLC6A2 | |
| SCHEMBL27558109 | 0.85 | GCK (0.47) | KCNH2FFAR1GCKSLC6A3SLC6A2 | |
| SCHEMBL27578470 | 0.85 | GCK (0.47) | KCNH2FFAR1GCKSLC6A3SLC6A2 | |
| SCHEMBL27575894 | 0.84 | ALDH1A1 (0.43) | KCNH2GCKPTGDRTBXA2RPDE2A | |
| SCHEMBL28749510 | 0.83 | FFAR1 (0.39) | KCNH2FFAR1GCKSLC6A3SLC6A2 | |
| SCHEMBL27635484 | 0.81 | SLC6A3 (0.44) | KCNH2GCKSLC6A3SLC6A2SLC6A4 | |
| SCHEMBL27765343 | 0.77 | GCK (0.42) | KCNH2GCKSLC6A3SLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101641447-A | Microbial reduction of acetoxy ketones | HOFFMANN LA ROCHE CH | 2010-02-03 | — | — | CN | disclosed |
| CN-101541756-A | Pyrazoles as glucokinase activators | HOFFMANN LA ROCHE (CH) | 2009-09-23 | — | — | CN | disclosed |
| CN-100469770-C | 5-substituted-pyrazine or -pyridine glucokinase activators | HOFFMANN LA ROCHE (CH) | 2009-03-18 | — | — | CN | disclosed |
| CN-1726197-A | 5-substituted-pyrazine or -pyridine glucokinase activators | HOFFMANN LA ROCHE (CH) | 2006-01-25 | — | — | CN | disclosed |
| CN-1226294-C | Fused heteroaromatic glucokinase activators | HOFFMANN LA ROCHE (CH) | 2005-11-09 | — | — | CN | disclosed |
| CN-1151140-C | Glucokinase activators | - | 2004-05-26 | — | — | CN | disclosed |
| CN-1476438-A | Fused heteroaromatic glucokinase activators | - | 2004-02-18 | — | — | CN | disclosed |
| CN-1349519-A | Glucokinase activators | HOFFMANN LA ROCHE (CH) | 2002-05-15 | — | — | CN | disclosed |