Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 4/20 | 0.44 |
| ▸ | FFAR1 | O14842 | 5/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | PTGDR | Q13258 | 8/20 | 0.40 |
| ▸ | TBXA2R | P21731 | 5/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.39 |
| ▸ | PDE2A | O00408 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27578470 | 0.93 | GCK (0.47) | GCKFFAR1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL27558109 | 0.93 | GCK (0.47) | GCKFFAR1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL27467646 | 0.90 | KCNH2 (0.46) | GCKFFAR1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL27502236 | 0.90 | KCNH2 (0.46) | GCKFFAR1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL27765336 | 0.88 | GCK (0.42) | GCKFFAR1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL27575894 | 0.83 | ALDH1A1 (0.43) | GCKPTGDRTBXA2RKCNH2PDE2A | |
| SCHEMBL28749510 | 0.81 | FFAR1 (0.39) | GCKFFAR1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL2642140 | 0.80 | GCK (0.48) | GCKKCNH2 | |
| SCHEMBL2653752 | 0.80 | GCK (0.50) | GCKSLC6A2SLC6A4SLC6A3KCNH2 | |
| SCHEMBL27578456 | 0.80 | GCK (0.50) | GCKSLC6A2SLC6A4SLC6A3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1329386-C | Substituted phenylacetamides and their use as glucokinase activators | HOFFMANN LA ROCHE CO LTD (CH) | 2007-08-01 | — | — | CN | disclosed |
| CN-1649859-A | Substituted phenylacetamides and their use as glucokinase activators | HOFFMANN LA ROCHE (CH) | 2005-08-03 | — | — | CN | disclosed |