Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.45 |
| ▸ | GCK | P35557 | 5/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 6/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.42 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.37 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.37 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27467646 | 0.89 | KCNH2 (0.46) | KCNH2GCKSLC6A3SLC6A2SLC6A4 | |
| SCHEMBL27502236 | 0.89 | KCNH2 (0.46) | KCNH2GCKSLC6A3SLC6A2SLC6A4 | |
| SCHEMBL27635484 | 0.81 | SLC6A3 (0.44) | KCNH2GCKSLC6A3SLC6A2SLC6A4 | |
| SCHEMBL27558086 | 0.79 | GCK (0.44) | KCNH2GCKSLC6A3SLC6A2SLC6A4 | |
| SCHEMBL2650827 | 0.76 | KCNH2 (0.62) | KCNH2GCKMEN1KMT2AADRA1D | |
| SCHEMBL27552958 | 0.76 | SLC6A3 (0.38) | SLC6A3SLC6A2SLC6A4EPHX1MEN1 | |
| SCHEMBL27765347 | 0.76 | GCK (0.42) | KCNH2GCKSLC6A3SLC6A2SLC6A4 | |
| SCHEMBL27765336 | 0.76 | GCK (0.42) | KCNH2GCKSLC6A3SLC6A2SLC6A4 | |
| SCHEMBL2647926 | 0.76 | KCNH2 (0.62) | KCNH2GCKMEN1KMT2AADRA1D | |
| SCHEMBL27765343 | 0.76 | GCK (0.42) | KCNH2GCKSLC6A3SLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101541756-A | Pyrazoles as glucokinase activators | HOFFMANN LA ROCHE (CH) | 2009-09-23 | — | — | CN | disclosed |
| CN-100469770-C | 5-substituted-pyrazine or -pyridine glucokinase activators | HOFFMANN LA ROCHE (CH) | 2009-03-18 | — | — | CN | disclosed |
| CN-1726197-A | 5-substituted-pyrazine or -pyridine glucokinase activators | HOFFMANN LA ROCHE (CH) | 2006-01-25 | — | — | CN | disclosed |