Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 2/20 | 0.48 |
| ▸ | NR3C1 | P04150 | 7/20 | 0.39 |
| ▸ | PGR | P06401 | 6/20 | 0.39 |
| ▸ | NR3C2 | P08235 | 6/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | HTR6 | P50406 | 1/20 | 0.36 |
| ▸ | AR | P10275 | 2/20 | 0.33 |
| ▸ | GLA | P06280 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | THRA | P10827 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5015442 | 0.77 | HTR2C (0.49) | HTR2CKDM4EHSD17B10HTR6ALDH1A1 | |
| SCHEMBL27656185 | 0.76 | NR3C1 (0.33) | NR3C1KDM4EHSD17B10 | |
| SCHEMBL28760998 | 0.75 | HTR2C (0.57) | HTR2CHTR6THRBALDH1A1 | |
| SCHEMBL27657110 | 0.73 | MTNR1A (0.39) | KDM4EHSD17B10ARALDH1A1 | |
| SCHEMBL4323537 | 0.71 | HTR2C (0.63) | HTR2CNR3C1PGRNR3C2KDM4E | |
| SCHEMBL29751560 | 0.71 | HTR2C (0.63) | HTR2CNR3C1PGRNR3C2KDM4E | |
| SCHEMBL3169119 | 0.70 | KMT2A (0.57) | HTR2CKDM4EHTR6GLAALDH1A1 | |
| SCHEMBL3874161 | 0.69 | ALDH1A1 (0.53) | HTR2CKDM4ELMNACYP3A4ALDH1A1 | |
| SCHEMBL6385676 | 0.69 | HTR2C (0.57) | HTR2CKDM4ELMNAALDH1A1 | |
| SCHEMBL4321418 | 0.69 | HTR2C (0.60) | HTR2CKDM4EHSD17B10HTR6LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1816550-B | Indolyl derivatives substituted with a thiazole ring and their use as PPAR modulators | HOFFMANN LA ROCHE | 2010-04-28 | — | — | CN | disclosed |
| CN-1816550-A | Indolyl derivatives substituted with a thiazole ring and their use as ppar modulators | HOFFMANN LA ROCHE (CH) | 2006-08-09 | — | — | CN | disclosed |