Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Acetylcysteine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.91 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.91 |
| ▸ | THRB | P10828 | 1/20 | 0.91 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.91 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.91 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.91 |
| ▸ | THPO | P40225 | 1/20 | 0.91 |
| ▸ | RECQL | P46063 | 1/20 | 0.91 |
| ▸ | BLM | P54132 | 1/20 | 0.91 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.91 |
| ▸ | ACE | P12821 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | FOLH1 | Q04609 | 3/20 | 0.48 |
| ▸ | CA1 | P00915 | 3/20 | 0.39 |
| ▸ | CA2 | P00918 | 3/20 | 0.39 |
| ▸ | GNPAT | O15228 | 1/20 | 0.39 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.38 |
| ▸ | NAALAD2 | Q9Y3Q0 | 2/20 | 0.36 |
| ▸ | FNTA | P49354 | 1/20 | 0.36 |
| ▸ | FNTB | P49356 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetylcysteine SCHEMBL27636692 | 1.00 | MAPT (0.91) | MAPTKDM4ETHRBALOX15NFKB1 | |
| Acetylcysteine SCHEMBL20915033 | 0.96 | MAPT (0.91) | MAPTKDM4ETHRBALOX15NFKB1 | |
| Acetylcysteine SCHEMBL1041788 | 0.96 | MAPT (0.91) | MAPTKDM4ETHRBALOX15NFKB1 | |
| Acetylcysteine SCHEMBL4437350 | 0.96 | MAPT (1.00) | MAPTKDM4ETHRBALOX15NFKB1 | |
| Acetylcysteine SCHEMBL4437351 | 0.96 | MAPT (1.00) | MAPTKDM4ETHRBALOX15NFKB1 | |
| Acetylcysteine SCHEMBL5291 | 0.96 | MAPT (1.00) | MAPTKDM4ETHRBALOX15NFKB1 | |
| Acetylcysteine SCHEMBL3923962 | 0.96 | MAPT (1.00) | MAPTKDM4ETHRBALOX15NFKB1 | |
| Acetylcysteine SCHEMBL149212 | 0.96 | MAPT (1.00) | MAPTKDM4ETHRBALOX15NFKB1 | |
| Acetylcysteine SCHEMBL1384791 | 0.96 | MAPT (1.00) | MAPTKDM4ETHRBALOX15NFKB1 | |
| Acetylcysteine SCHEMBL5292 | 0.96 | MAPT (1.00) | MAPTKDM4ETHRBALOX15NFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1799537-A | Preparation method and clinical application of acetylcysteine powdered injection and acetylcysteine infusion | JIANG JIANGUO (CN) | 2006-07-12 | — | — | CN | claimed |
| CN-103421205-B | Surface modifying method and surface modified elastic body | 住友橡胶工业株式会社 | 2019-07-23 | — | — | CN | disclosed |
| CN-104769026-B | Surface modifying method and surface modified elastic body | 住友橡胶工业株式会社 | 2018-09-18 | — | — | CN | disclosed |
| CN-101239037-B | Acetylcysteine injection and preparation thereof | HANGZHOU SHENGYOU MEDICINE TECHNOLOGY DEV CO LTD | 2010-12-22 | — | — | CN | disclosed |
| CN-101239037-A | Acetylcysteine injection and preparation thereof | HANGZHOU SHENGYOU MEDICINE TEC (CN) | 2008-08-13 | — | — | CN | disclosed |
| CN-1799537-A | Preparation method and clinical application of acetylcysteine powdered injection and acetylcysteine infusion | JIANG JIANGUO (CN) | 2006-07-12 | — | — | CN | disclosed |