Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 8/20 | 0.56 |
| ▸ | CA1 | P00915 | 7/20 | 0.56 |
| ▸ | CA9 | Q16790 | 6/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | GPR3 | P46089 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | CA12 | O43570 | 4/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.42 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.42 |
| ▸ | FEN1 | P39748 | 2/20 | 0.42 |
| ▸ | CA4 | P22748 | 2/20 | 0.39 |
| ▸ | CA6 | P23280 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CA5A | P35218 | 1/20 | 0.39 |
| ▸ | CA7 | P43166 | 1/20 | 0.39 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.39 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.39 |
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL329916 | 0.87 | KDM4E (0.50) | CA2CA1CA9KDM4EGPR3 | |
| SCHEMBL9780253 | 0.86 | KDM4E (0.49) | CA2CA1CA9KDM4EGPR3 | |
| SCHEMBL329917 | 0.86 | KDM4E (0.49) | CA2CA1CA9KDM4EGPR3 | |
| SCHEMBL30857515 | 0.79 | KDM4E (0.61) | KDM4EGPR3MAPK1TP53CYP1A2 | |
| Benzene SCHEMBL12471481 | 0.78 | ALDH1A1 (0.51) | CA2CA1CA9KDM4EGPR3 | |
| SCHEMBL841678 | 0.76 | KDM4E (0.57) | KDM4EGPR3CYP2C9TP53CYP1A2 | |
| SCHEMBL241588 | 0.76 | KDM4E (0.57) | KDM4EGPR3CYP1A2MAPTHPGD | |
| SCHEMBL29598792 | 0.76 | KDM4E (0.57) | KDM4EGPR3CYP1A2MAPTHPGD | |
| SCHEMBL329200 | 0.76 | KDM4E (0.57) | KDM4EGPR3CYP1A2MAPTHPGD | |
| SCHEMBL329543 | 0.76 | KDM4E (0.57) | KDM4EGPR3CYP1A2MAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1905864-B | DNA damage repair inhibitors for the treatment of cancer | KUDOS PHARM LTD | 2011-04-06 | — | — | CN | disclosed |
| CN-1905864-A | DNA damage repair inhibitors for the treatment of cancer | KUDOS PHARM LTD (GB) | 2007-01-31 | — | — | CN | disclosed |
| CN-1720231-A | Substituted dihydrophenanthridinesulfonamides | WYETH CORP (US) | 2006-01-11 | — | — | CN | disclosed |