Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 4/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | RXFP4 | Q8TDU9 | 1/20 | 0.34 |
| ▸ | RXFP3 | Q9NSD7 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 2/20 | 0.34 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | ACHE | P22303 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.32 |
| ▸ | CLK2 | P49760 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20674516 | 0.77 | AR (0.39) | CYP3A4BRPF1CYP1A2CYP2C19ACHE | |
| SCHEMBL20688241 | 0.77 | MAPT (0.50) | CYP3A4ATMBRPF1CYP1A2CYP2C19 | |
| SCHEMBL20674101 | 0.76 | IKBKB (0.39) | ATMBRPF1ALDH1A1 | |
| SCHEMBL21958611 | 0.75 | GLO1 (0.34) | ALDH1A1 | |
| SCHEMBL1144808 | 0.74 | GSK3B (0.36) | CYP3A4ATMBRPF1CYP1A2CYP2C19 | |
| SCHEMBL30858656 | 0.74 | AR (0.48) | CYP3A4ATMBRPF1CYP1A2CYP2C19 | |
| SCHEMBL29226865 | 0.74 | LMNA (0.41) | CYP3A4BRPF1ACHEALDH1A1MEN1 | |
| SCHEMBL30234188 | 0.74 | LMNA (0.41) | CYP3A4BRPF1ACHEALDH1A1MEN1 | |
| SCHEMBL20674478 | 0.73 | LMNA (0.38) | ALDH1A1KMT2ALMNAPOLB | |
| SCHEMBL1144695 | 0.72 | NOTUM (0.47) | CYP3A4ALOX15BRPF1CYP1A2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1863794-A | Quinazoline derivatives as angiogenesis inhibitors | ASTRAZENECA AB (SE) | 2006-11-15 | — | — | CN | disclosed |