Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.61 |
| ▸ | DGKA | P23743 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | HTR2C | P28335 | 1/20 | 0.47 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.46 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.46 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.46 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | BLM | P54132 | 1/20 | 0.45 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | NAAA | Q02083 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26238717 | 0.98 | TSHR (0.58) | TSHRDGKALMNAALDH1A1HTR2C | |
| SCHEMBL429505 | 0.95 | TSHR (0.61) | TSHRDGKALMNAALDH1A1HTR2C | |
| SCHEMBL26238693 | 0.90 | DGKA (0.71) | TSHRDGKALMNAALDH1A1HTR2C | |
| SCHEMBL26238721 | 0.90 | DGKA (0.71) | TSHRDGKALMNAALDH1A1HTR2C | |
| SCHEMBL25953980 | 0.90 | DGKA (0.66) | TSHRDGKAHTR2CPRSS1PRSS2 | |
| SCHEMBL26832128 | 0.90 | TSHR (0.54) | TSHRDGKALMNAALDH1A1HTR2C | |
| SCHEMBL27736720 | 0.90 | DGKA (0.70) | TSHRDGKAHTR2CPRSS1PRSS2 | |
| SCHEMBL18266869 | 0.90 | ALDH1A1 (0.55) | TSHRDGKALMNAALDH1A1HTR2C | |
| SCHEMBL14500172 | 0.89 | TSHR (0.56) | TSHRDGKALMNAALDH1A1HTR2C | |
| SCHEMBL714030 | 0.88 | TSHR (0.52) | TSHRDGKALMNAALDH1A1HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106459049-A | Tyrosine kinase inhibitors | 普林斯匹亚生物制药公司 | 2017-02-22 | — | — | CN | disclosed |
| CN-101496794-B | Enteric long-acting coating core and medicament dosage form and method for producing the same | HUANENG PHARMACEUTICALS CO LTD | 2013-12-11 | — | — | CN | disclosed |
| CN-102908331-A | Duloxetine hydrochloride enteric capsules and preparation method thereof | ZHEJIANG JIUZHOU PHARMACEUTICAL TECHNOLOGY CO LTD | 2013-02-06 | — | — | CN | disclosed |
| CN-101496794-A | Enteric long-acting coated core and pharmaceutical dosage form and method for producing the same | TAIWAN BIOTECHNOLOGY CO LTD (CN) | 2009-08-05 | — | — | CN | disclosed |
| CN-100362997-C | Enteric coated table of duloxetine, and preparation method | SHANGHAI INST OF MEDICINE IND (CN) | 2008-01-23 | — | — | CN | disclosed |
| CN-100362996-C | Duloxetine enteric coated tiny pill capsule, and preparation method | SHANGHAI INST OF MEDICINE IND (CN) | 2008-01-23 | — | — | CN | disclosed |
| CN-1759830-A | Enteric coated table of duloxetine, and preparation method | SHANGHAI INST OF MEDICINE IND (CN) | 2006-04-19 | — | — | CN | disclosed |
| CN-1759829-A | Duloxetine enteric coated tiny pill capsule, and preparation method | SHANGHAI INST OF MEDICINE IND (CN) | 2006-04-19 | — | — | CN | disclosed |