Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 4/20 | 0.41 |
| ▸ | ADRA2B | P18089 | 4/20 | 0.41 |
| ▸ | ADRA2C | P18825 | 4/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.41 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.41 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | HTR7 | P34969 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27676600 | 0.77 | IDO1 (0.34) | — | |
| SCHEMBL27676438 | 0.76 | DAO (0.34) | — | |
| SCHEMBL21696322 | 0.75 | ADRA2A (0.42) | ADRA2AADRA2BADRA2CADRA1AADRA1B | |
| SCHEMBL1053969 | 0.68 | TSHR (0.55) | ADRA2AADRA2BADRA2CADRA1AADRA1B | |
| SCHEMBL13218794 | 0.67 | ADRA2A (0.42) | ADRA2AADRA2BADRA2CADRA1AADRA1B | |
| SCHEMBL14439671 | 0.67 | ADRA2A (0.42) | ADRA2AADRA2BADRA2CADRA1AADRA1B | |
| SCHEMBL13218812 | 0.67 | ADRA2A (0.42) | ADRA2AADRA2BADRA2CADRA1AADRA1B | |
| SCHEMBL4260014 | 0.66 | ADRA2A (0.44) | ADRA2AADRA2BADRA2CADRA1AADRA1B | |
| SCHEMBL28239409 | 0.66 | ADRA2A (0.44) | ADRA2AADRA2BADRA2CADRA1AADRA1B | |
| SCHEMBL28002684 | 0.65 | DCUN1D1 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107847492-A | Composition for improving distance vision and treating ametropia of eyes | 远视眼治疗有限责任公司 | 2018-03-27 | — | — | CN | disclosed |
| CN-100417379-C | Nonsedating alpha-2 agonist 1- (2, 3-dimethyl-phenyl) -ethyl-1, 3-dihydro-imizadole-2-thione | ALLERGAN INC (US) | 2008-09-10 | — | — | CN | disclosed |
| CN-1849118-A | Nonsedating alpha-2 agonist 1- (2, 3-dimethyl-phenyl) -ethyl-1, 3-dihydro-imizadole-2-thione | ALLERGAN INC (US) | 2006-10-18 | — | — | CN | disclosed |