Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Dl-Tryptophan. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | TSHR | P16473 | 2/20 | 0.57 |
| ▸ | BLM | P54132 | 2/20 | 0.57 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | MPO | P05164 | 1/20 | 0.57 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.57 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.51 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | HTR1A | P08908 | 1/20 | 0.49 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.49 |
| ▸ | HTR2A | P28223 | 1/20 | 0.49 |
| ▸ | HTR2C | P28335 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dl-Tryptophan SCHEMBL28079150 | 1.00 | KMT2A (0.57) | KMT2AKDM4ELMNAMAPTTSHR | |
| Dl-Tryptophan SCHEMBL29076836 | 0.99 | KMT2A (0.58) | KMT2AKDM4ELMNAMAPTTSHR | |
| Dl-Tryptophan SCHEMBL27660745 | 0.95 | KMT2A (0.63) | KMT2AKDM4ELMNAMAPTTSHR | |
| Dl-Tryptophan SCHEMBL27641172 | 0.92 | IL23R (0.50) | KMT2AKDM4ELMNAMAPTTSHR | |
| Dl-Tryptophan SCHEMBL28131402 | 0.92 | KMT2A (0.58) | KMT2AKDM4ELMNAMAPTTSHR | |
| Dl-Tryptophan SCHEMBL28861116 | 0.92 | KMT2A (0.58) | KMT2AKDM4ELMNAMAPTTSHR | |
| Dl-Tryptophan SCHEMBL20164946 | 0.92 | KDM4E (0.68) | KMT2AKDM4ELMNAMAPTTSHR | |
| Dl-Tryptophan SCHEMBL1533586 | 0.92 | KDM4E (0.68) | KMT2AKDM4ELMNAMAPTTSHR | |
| Tryptophan SCHEMBL530950 | 0.92 | KDM4E (0.68) | KMT2AKDM4ELMNAMAPTTSHR | |
| Dl-Tryptophan SCHEMBL28512622 | 0.92 | KDM4E (0.68) | KMT2AKDM4ELMNAMAPTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1938042-A | Methods for mitigating oxidative damage | CORNELL RES FOUNDATION INC (US) | 2007-03-28 | — | — | CN | disclosed |
| CN-1787831-A | Method for preventing mitochondrial permeability transition | CORNELL RES FOUNDATION INC (US) | 2006-06-14 | — | — | CN | disclosed |