Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.44 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.44 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.44 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.44 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.44 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.44 |
| ▸ | MET | P08581 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3854380 | 0.86 | HTR1A (0.49) | ALDH1A1KDM4ELMNAMEN1KMT2A | |
| Bromide SCHEMBL27662427 | 0.85 | MEN1 (0.50) | ALDH1A1KDM4ELMNAMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL3851017 | 0.84 | NPC1 (0.41) | ALDH1A1LMNAKMT2ANPC1MAPT | |
| Bromide SCHEMBL3853194 | 0.79 | ALDH1A1 (0.56) | ALDH1A1KDM4ELMNAMEN1KMT2A | |
| SCHEMBL28841407 | 0.78 | ALDH1A1 (0.54) | ALDH1A1KDM4ELMNAMEN1KMT2A | |
| SCHEMBL27662644 | 0.77 | ALDH1A1 (0.52) | ALDH1A1KDM4ELMNAMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL3854520 | 0.76 | ALDH1A1 (0.47) | ALDH1A1KDM4ENPC1MAPTRAB9A | |
| SCHEMBL29793985 | 0.75 | GRIN2B (0.49) | ALDH1A1KDM4EMEN1KMT2ANPC1 | |
| SCHEMBL28953119 | 0.75 | GRIN2B (0.49) | ALDH1A1KDM4EMEN1KMT2ANPC1 | |
| Hydrochloric Acid SCHEMBL3848508 | 0.72 | GSK3B (0.46) | ALDH1A1KDM4EMEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100460395-C | Aromatic-cyclo and heterocyclo acylmethyl imidazole salts compound and method for preparing same | UNIV YUNNAN (CN) | 2009-02-11 | — | — | CN | disclosed |
| CN-1884266-A | Aromatic-cyclo and heterocyclo acylmethyl imidazole salts compound and method for preparing same | UNIV YUNNAN (CN) | 2006-12-27 | — | — | CN | disclosed |