Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.50 |
| ▸ | HPGD | P15428 | 5/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2764515 | 0.85 | KDM4E (0.50) | KDM4EALDH1A1HPGDL3MBTL1MAPT | |
| SCHEMBL4271339 | 0.84 | KDM4E (0.53) | KDM4EALDH1A1HPGDMAPTSMN1; SMN2 | |
| SCHEMBL5762224 | 0.81 | PTPN11 (0.44) | KDM4EALDH1A1HPGDL3MBTL1MAPT | |
| SCHEMBL2766091 | 0.80 | DRD2 (0.52) | KDM4EALDH1A1HPGDL3MBTL1MAPT | |
| SCHEMBL4279483 | 0.78 | SMN1; SMN2 (0.56) | KDM4EALDH1A1HPGDMAPTSMN1; SMN2 | |
| SCHEMBL2764403 | 0.77 | DRD2 (0.49) | KDM4EALDH1A1HPGDL3MBTL1MAPT | |
| SCHEMBL4277755 | 0.77 | ALDH1A1 (0.44) | KDM4EALDH1A1HPGDMAPTSMN1; SMN2 | |
| SCHEMBL5761885 | 0.76 | PTPN11 (0.47) | SMN1; SMN2GAAPTPN11NPC1HTT | |
| SCHEMBL4271678 | 0.75 | ALDH1A1 (0.43) | KDM4EALDH1A1HPGDMAPTSMN1; SMN2 | |
| SCHEMBL38656222 | 0.75 | CHEK1 (0.43) | ALDH1A1HPGDMAPTSMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1400515-B1 | CYCLIC DIAMINE COMPOUND HAVING FIVE-MEMBERED CYCLIC GROUP | KOWA CO (JP) | 2010-04-14 | — | — | EP | disclosed |
| CN-100491355-C | Cyclic diamine compound having five-membered cyclic group | KOWA CO (JP) | 2009-05-27 | — | — | CN | disclosed |
| CN-1522250-A | Cyclic diamine compound having five-membered cyclic group | ������������ʽ���� | 2004-08-18 | — | — | CN | disclosed |
| EP-1400515-A1 | CYCLIC DIAMINE COMPOUND HAVING FIVE-MEMBERED CYCLIC GROUP | Kowa Co., Ltd. (JP) | 2004-03-24 | — | — | EP | disclosed |
| US-6472386-B1 | Cyclic diamine compound with 5-membered ring groups | KOWA CO., LTD. (JP) | 2002-10-29 | — | — | US | disclosed |