SCHEMBL276426

SCHEMBL276426

Oc1cccc2cncnc12

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
METAP2 P50579 2/20 0.55
MMP2 P08253 1/20 0.55
CHRM1 P11229 1/20 0.55
TSHR P16473 1/20 0.55
COMT P21964 1/20 0.55
ADRA1A P35348 1/20 0.55
METAP1 P53582 1/20 0.55
HDAC8 Q9BY41 1/20 0.55
KDM4E B2RXH2 10/20 0.52
ALOX12 P18054 3/20 0.47
MAPKAPK2 P49137 1/20 0.47
EGFR P00533 1/20 0.47
ACHE P22303 1/20 0.45
PLAU P00749 1/20 0.42
NCF1 P14598 1/20 0.42
ALDH1A1 P00352 3/20 0.41
CYP1A2 P05177 1/20 0.41
CYP3A4 P08684 1/20 0.41
CYP2C9 P11712 1/20 0.41
HPGD P15428 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL28754132 0.98 METAP2 (0.53) METAP2MMP2CHRM1TSHRCOMT
Thiourea SCHEMBL3241360 0.91 METAP2 (0.47) METAP2MMP2CHRM1TSHRCOMT
Quinazoline SCHEMBL561027 0.89 EGFR (0.67) METAP2MMP2CHRM1TSHRCOMT
SCHEMBL11798326 0.87 TSHR (0.51) METAP2MMP2CHRM1TSHRCOMT
Trifluoroacetic Acid SCHEMBL29618258 0.85 PAX8 (0.56) METAP2MMP2CHRM1TSHRCOMT
Trifluoroacetic Acid SCHEMBL29618251 0.85 PAX8 (0.56) METAP2MMP2CHRM1TSHRCOMT
SCHEMBL27527609 0.83 EGFR (0.44) METAP2MMP2CHRM1TSHRCOMT
SCHEMBL12747762 0.79 EGFR (0.47) METAP2MMP2CHRM1TSHRCOMT
SCHEMBL3074807 0.78 EGFR (0.50) MMP2TSHRKDM4EEGFRALDH1A1
SCHEMBL559673 0.77 EGFR (0.48) KDM4EEGFRCYP1A2CYP3A4CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 249 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118239931-A As P2X3Aminoquinazoline derivatives of inhibitors 奇斯药制品公司 2024-06-25 CN claimed
CN-114269432-B As P2X3Aminoquinazoline derivatives of inhibitors 奇斯药制品公司 2024-05-07 CN claimed
CN-114269432-A As P2X3Aminoquinazoline derivatives as inhibitors 奇斯药制品公司 2022-04-01 CN claimed
EP-2493956-B1 MOISTURE-CURING FORMULATIONS WITH TIME-MODIFIED CURING BEHAVIOR HENKEL AG & CO KGAA (DE) 2018-04-18 EP claimed
WO-2016154694-A1 N-ACYLHYDRAZONE COMPOUNDS INHIBITING HISTONE DESACETYLASE ENZYMES, PHARMACEUTICAL COMPOSITIONS CONTAINING SAME, AND METHOD FOR PRODUCING SAME UNIVERSIDADE FEDERAL DO RIO DE JANEIRO-UFRJ (BR) 2016-10-06 WO claimed
EP-3074482-A1 ENCODED CHROMOPHORIC POLYMER PARTICLES University Of Washington Through Its Center For Commercialization (US) 2016-10-05 EP claimed
CN-102712751-B Moisture-curing formulations with time-modified phases HENKEL AG & CO KGAA 2015-06-10 CN claimed
WO-2015081126-A1 ENCODED CHROMOPHORIC POLYMER PARTICLES UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION (US) 2015-06-04 WO claimed
US-8592517-B2 Moisture-curing formulations with time-modified phases HENKEL AG & CO. KGAA (DE) 2013-11-26 US claimed
US-20120277373-A1 MOISTURE-CURING FORMULATIONS WITH TIME-MODIFIED PHASES HENKEL AG & CO. KGAA (DE) 2012-11-01 US claimed
EP-1558585-A4 NEUROLOGICALLY-ACTIVE COMPOUNDS PRANA BIOTECHNOLOGY LTD (AU) 2008-07-02 EP claimed
CN-1720238-A Neurologically-active compounds PRANA BIOTECHNOLOGY LTD (AU) 2006-01-11 CN claimed
EP-1558585-A1 NEUROLOGICALLY-ACTIVE COMPOUNDS Prana Biotechnology Ltd (AU) 2005-08-03 EP claimed
WO-2004031161-A1 NEUROLOGICALLY-ACTIVE COMPOUNDS PRANA BIOTECHNOLOGY LIMITED (AU) 2004-04-15 WO claimed
US-5385990-A Blend of epoxy compound, amine hardener and hydroxy substituted aromatic compound LORD CORPORATION (US) 1995-01-31 US claimed
CN-1087367-A Structural adhesive composition with high temperature resistance LORD CORP (US) 1994-06-01 CN claimed
EP-0596622-A2 Epoxy resin structural adhesive composition having high temperature resistance LORD CORPORATION (US) 1994-05-11 EP claimed
EP-0377357-B1 Process for the condensation of at least one epoxide on at least one cyclic anhyhride in the presence of a titanium-based catalyst INST FRANCAIS DU PETROLE (FR) 1994-03-23 EP claimed
US-5183919-A Process for the preparation of diaryl carbonates THE DOW CHEMICAL COMPANY (US) 1993-02-02 US claimed
US-4714614-A PSEUDOMONAS AND FERRIC ION CHELATING AGENT COLORADO STATE UNIVERSITY (US) 1987-12-22 US claimed