Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 3/20 | 0.97 |
| ▸ | MAOB | P27338 | 3/20 | 0.97 |
| ▸ | KCNH2 | Q12809 | 12/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.59 |
| ▸ | RIOK2 | Q9BVS4 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | ALPL | P05186 | 1/20 | 0.49 |
| ▸ | ALPI | P09923 | 1/20 | 0.49 |
| ▸ | ALPG | P10696 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29351256 | 0.98 | MAOA (1.00) | MAOAMAOBKCNH2ALDH1A1TSHR | |
| SCHEMBL407010 | 0.98 | MAOA (1.00) | MAOAMAOBKCNH2ALDH1A1TSHR | |
| SCHEMBL407009 | 0.98 | MAOA (1.00) | MAOAMAOBKCNH2ALDH1A1TSHR | |
| SCHEMBL1131920 | 0.98 | MAOA (1.00) | MAOAMAOBKCNH2ALDH1A1TSHR | |
| SCHEMBL20865430 | 0.79 | MAOA (0.71) | MAOAMAOBKCNH2ALDH1A1TDP1 | |
| SCHEMBL670018 | 0.78 | MAOA (1.00) | MAOAMAOBKCNH2ALDH1A1TDP1 | |
| SCHEMBL670019 | 0.78 | MAOA (1.00) | MAOAMAOBKCNH2ALDH1A1TDP1 | |
| SCHEMBL2561900 | 0.76 | MAOA (0.96) | MAOAMAOBKCNH2ALDH1A1TDP1 | |
| SCHEMBL2561898 | 0.76 | MAOA (0.96) | MAOAMAOBKCNH2ALDH1A1TDP1 | |
| SCHEMBL4961652 | 0.76 | MAOA (0.62) | MAOAMAOBKCNH2RIOK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1891691-A | Symmetrical diazo compounds, compositions comprising them, method of coloring, and device | OREAL (FR) | 2007-01-10 | — | — | CN | disclosed |