Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SERPINE1 | P05121 | 9/20 | 0.66 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.48 |
| ▸ | PTGES2 | Q9H7Z7 | 4/20 | 0.47 |
| ▸ | PTGES | O14684 | 2/20 | 0.47 |
| ▸ | PPARG | P37231 | 2/20 | 0.47 |
| ▸ | ICMT | O60725 | 2/20 | 0.46 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.43 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27643170 | 0.98 | SERPINE1 (0.63) | SERPINE1PLA2G2APTGES2PTGESPPARG | |
| SCHEMBL27643178 | 0.82 | SERPINE1 (0.50) | SERPINE1PLA2G2AICMTMAPK8 | |
| SCHEMBL27643855 | 0.82 | SERPINE1 (0.52) | SERPINE1PLA2G2AMAPK8 | |
| SCHEMBL4887373 | 0.80 | SERPINE1 (0.55) | SERPINE1PLA2G2APPARGMAPK8 | |
| SCHEMBL4980302 | 0.79 | SERPINE1 (1.00) | SERPINE1PTGES2PTGESPPARG | |
| SCHEMBL4893009 | 0.76 | PLA2G2A (0.51) | SERPINE1PLA2G2APTGES2PTGESMAPK8 | |
| SCHEMBL4891631 | 0.75 | AR (0.56) | SERPINE1PLA2G2A | |
| SCHEMBL5812761 | 0.75 | PTGES (0.65) | SERPINE1PLA2G2APTGESPPARG | |
| SCHEMBL4982359 | 0.75 | SERPINE1 (0.92) | SERPINE1PTGES2PTGESPPARGMAPK8 | |
| SCHEMBL13168309 | 0.74 | SERPINE1 (0.49) | SERPINE1PLA2G2APPARGMAPK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1890214-A | Heterocyclic- or aryloxy, -thio or -amino substituted indoles-2-carboxylic acids or esters as pai-1 | WYETH CORP (US) | 2007-01-03 | — | — | CN | disclosed |