Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SERPINE1 | P05121 | 5/20 | 0.50 |
| ▸ | EDNRB | P24530 | 4/20 | 0.46 |
| ▸ | EDNRA | P25101 | 4/20 | 0.46 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.46 |
| ▸ | MAPK8 | P45983 | 8/20 | 0.46 |
| ▸ | ICMT | O60725 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27643170 | 0.85 | SERPINE1 (0.63) | SERPINE1PLA2G2AMAPK8ICMT | |
| SCHEMBL27643174 | 0.82 | SERPINE1 (0.66) | SERPINE1PLA2G2AMAPK8ICMT | |
| SCHEMBL27643855 | 0.80 | SERPINE1 (0.52) | SERPINE1EDNRBEDNRAPLA2G2AMAPK8 | |
| SCHEMBL27664461 | 0.77 | SERPINE1 (0.66) | SERPINE1EDNRBEDNRAPLA2G2AMAPK8 | |
| SCHEMBL6093339 | 0.75 | SERPINE1 (0.61) | SERPINE1EDNRBEDNRA | |
| SCHEMBL4886339 | 0.73 | PLA2G2A (0.55) | SERPINE1PLA2G2AMAPK8 | |
| SCHEMBL4893009 | 0.72 | PLA2G2A (0.51) | SERPINE1PLA2G2AMAPK8 | |
| SCHEMBL4980145 | 0.71 | SERPINE1 (0.81) | SERPINE1EDNRBEDNRAPLA2G2AMAPK8 | |
| SCHEMBL6092353 | 0.71 | SERPINE1 (0.56) | SERPINE1EDNRBEDNRA | |
| SCHEMBL27643179 | 0.71 | SERPINE1 (0.44) | SERPINE1EDNRBEDNRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1890214-A | Heterocyclic- or aryloxy, -thio or -amino substituted indoles-2-carboxylic acids or esters as pai-1 | WYETH CORP (US) | 2007-01-03 | — | — | CN | disclosed |