Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SERPINE1 | P05121 | 5/20 | 0.66 |
| ▸ | EDNRB | P24530 | 5/20 | 0.48 |
| ▸ | EDNRA | P25101 | 5/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | CFD | P00746 | 1/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.41 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.39 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.39 |
| ▸ | KLK1 | P06870 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4980145 | 0.89 | SERPINE1 (0.81) | SERPINE1EDNRBEDNRAPOLBMAPK8 | |
| SCHEMBL4982128 | 0.88 | SERPINE1 (0.68) | SERPINE1EDNRBEDNRAPOLBMAPK8 | |
| SCHEMBL4982359 | 0.83 | SERPINE1 (0.92) | SERPINE1EDNRBEDNRAMAPK8FOLH1 | |
| SCHEMBL5419800 | 0.81 | SERPINE1 (0.66) | SERPINE1EDNRBEDNRAPOLBMAPK8 | |
| SCHEMBL4980302 | 0.80 | SERPINE1 (1.00) | SERPINE1EDNRBEDNRA | |
| SCHEMBL4986284 | 0.79 | SERPINE1 (0.57) | SERPINE1EDNRBEDNRAPOLBMAPK8 | |
| SCHEMBL4887004 | 0.77 | SERPINE1 (1.00) | SERPINE1EDNRBEDNRAPOLBMAPK8 | |
| SCHEMBL27643178 | 0.77 | SERPINE1 (0.50) | SERPINE1EDNRBEDNRAMAPK8PLA2G2A | |
| SCHEMBL4884301 | 0.76 | SERPINE1 (0.80) | SERPINE1EDNRBEDNRAMAPK8 | |
| SCHEMBL4892537 | 0.75 | SERPINE1 (1.00) | SERPINE1EDNRBEDNRAMAPK8MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1890214-A | Heterocyclic- or aryloxy, -thio or -amino substituted indoles-2-carboxylic acids or esters as pai-1 | WYETH CORP (US) | 2007-01-03 | — | — | CN | claimed |