Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | IRAK1 | P51617 | 3/20 | 0.35 |
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
| ▸ | CASP7 | P55210 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27645259 | 0.85 | PDGFRB (0.40) | ALDH1A1EPHX2HTR1AMAPTSMN1; SMN2 | |
| SCHEMBL2091521 | 0.79 | CHEK2 (0.42) | ALDH1A1IRAK1IRAK4MEN1CASP1 | |
| SCHEMBL246244 | 0.71 | ALDH1A1 (0.53) | ALDH1A1MAPTKDM4EGAASMN1; SMN2 | |
| SCHEMBL2090809 | 0.70 | MTOR (0.39) | EPHX2IRAK1IRAK4GAAPDE4B | |
| SCHEMBL15275374 | 0.68 | NCF1 (0.46) | ALDH1A1IRAK4MAPTKDM4EGAA | |
| SCHEMBL15275373 | 0.68 | IRAK4 (0.46) | ALDH1A1IRAK4MAPTKDM4EGAA | |
| SCHEMBL5542743 | 0.65 | ALDH1A1 (0.53) | ALDH1A1MAPTKDM4EGAASMN1; SMN2 | |
| SCHEMBL2091712 | 0.64 | ALDH1A1 (0.40) | ALDH1A1MAPTKDM4ESMN1; SMN2MEN1 | |
| SCHEMBL359830 | 0.64 | IRAK1 (0.52) | IRAK1IRAK4 | |
| SCHEMBL2091518 | 0.64 | CXCR4 (0.43) | IRAK1IRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100497345-C | 2, 3-dihydro-6-nitroimidazolo [2,1-b] oxazole compounds for the treatment of tuberculosis | OTSUKA PHARMA CO LTD (JP) | 2009-06-10 | — | — | CN | disclosed |
| CN-1878777-A | 2,3-dihydro-6-nitroimidazo (2,1-b) oxazole compounds for the treatment of tuberculosis | OTSUKA PHARMA CO LTD (JP) | 2006-12-13 | — | — | CN | disclosed |