Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 1/20 | 0.40 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 4/20 | 0.37 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.34 |
| ▸ | P2RX2 | Q9UBL9 | 1/20 | 0.34 |
| ▸ | MAT2A | P31153 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27645262 | 0.85 | ALDH1A1 (0.37) | HTR1AALDH1A1MAPTSMN1; SMN2EPHX2 | |
| SCHEMBL2090809 | 0.70 | MTOR (0.39) | LMNAEPHX2 | |
| SCHEMBL15275374 | 0.68 | NCF1 (0.46) | PDGFRBPDGFRAPDE10AALDH1A1MAPT | |
| SCHEMBL15275373 | 0.68 | IRAK4 (0.46) | PDGFRBPDGFRAPDE10AALDH1A1MAPT | |
| SCHEMBL30152773 | 0.66 | PDGFRB (0.62) | PDGFRBPDGFRAPDE3BPDE3APDE10A | |
| SCHEMBL244602 | 0.65 | PDGFRB (0.77) | PDGFRBPDGFRAPDE10AALDH1A1LMNA | |
| SCHEMBL2091521 | 0.64 | CHEK2 (0.42) | PDE10AALDH1A1 | |
| SCHEMBL2091518 | 0.64 | CXCR4 (0.43) | PDE10A | |
| SCHEMBL8404544 | 0.64 | ALDH1A1 (0.61) | PDGFRBPDGFRAALDH1A1LMNAMAPT | |
| SCHEMBL31186675 | 0.64 | ALDH1A1 (0.61) | PDGFRBPDGFRAALDH1A1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100497345-C | 2, 3-dihydro-6-nitroimidazolo [2,1-b] oxazole compounds for the treatment of tuberculosis | OTSUKA PHARMA CO LTD (JP) | 2009-06-10 | — | — | CN | disclosed |
| CN-1878777-A | 2,3-dihydro-6-nitroimidazo (2,1-b) oxazole compounds for the treatment of tuberculosis | OTSUKA PHARMA CO LTD (JP) | 2006-12-13 | — | — | CN | disclosed |