Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3GNRHRMPLPDE3APDE3BPDE4APDE4BPDE4CPDE4DPPARASLC5A2
The experimentally established mechanism targets of Choline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA known ✓ | Q07869 | 1/20 | 0.37 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.46 |
| ▸ | BID | P55957 | 3/20 | 0.37 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.37 |
| ▸ | BCL2L1 | Q07817 | 2/20 | 0.37 |
| ▸ | BAK1 | Q16611 | 2/20 | 0.37 |
| ▸ | KAT8 | Q9H7Z6 | 2/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | EP300 | Q09472 | 1/20 | 0.37 |
| ▸ | KAT2A | Q92830 | 1/20 | 0.37 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.37 |
| ▸ | KAT5 | Q92993 | 1/20 | 0.37 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.37 |
| ▸ | THRA | P10827 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cetrimonium SCHEMBL330808 | 0.91 | LIPG (0.45) | LIPGLMNACYP2D6CYP2C9TSHR | |
| SCHEMBL330544 | 0.91 | LIPG (0.45) | LIPGLMNACYP2D6CYP2C9TSHR | |
| SCHEMBL330654 | 0.91 | LIPG (0.45) | LIPGLMNACYP2D6CYP2C9TSHR | |
| SCHEMBL4613048 | 0.90 | DNM1 (0.49) | LIPGLMNAHTTKCNH2HIF1A | |
| Tetramethylammonium Ion SCHEMBL330911 | 0.88 | LIPG (0.50) | LIPGBIDMCL1BCL2L1BAK1 | |
| Choline SCHEMBL28319324 | 0.87 | LIPG (0.42) | LIPGBIDMCL1BCL2L1BAK1 | |
| SCHEMBL16895142 | 0.86 | LIPG (0.54) | LIPGBIDMCL1BCL2L1BAK1 | |
| SCHEMBL330887 | 0.85 | MLNR (0.47) | LIPGLMNAHTTKCNH2HIF1A | |
| Didecyldimethylammonium SCHEMBL332030 | 0.85 | MLNR (0.47) | LIPGLMNAHTTKCNH2HIF1A | |
| SCHEMBL330692 | 0.85 | LIPG (0.45) | LIPGLMNACYP2D6CYP2C9TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5007955-A | Applying quaternary ammonium sulfonates to weeds | DAI-ICHI KOGYO SEIYAKU CO., LTD. (JP) | 1991-04-16 | — | — | US | claimed |
| EP-3080184-B1 | COATING COMPOSITIONS COMPRISING A BLOCKED ISOCYANATE SILANE | SDC TECH INC (US) | 2020-09-30 | — | — | EP | disclosed |
| US-9657194-B2 | Coating compositions comprising a blocked isocyanate silane | SDC TECHNOLOGIES, INC. (US) | 2017-05-23 | — | — | US | disclosed |
| EP-3080184-A1 | COATING COMPOSITIONS COMPRISING A BLOCKED ISOCYANATE SILANE | SDC Technologies, Inc. (US) | 2016-10-19 | — | — | EP | disclosed |
| EP-1937755-B1 | ANTI-FOG FILM ASSEMBLIES, METHOD OF MANUFACTURE, AND ARTICLES MADE THEREOF | SABIC GLOBAL TECHNOLOGIES BV (NL) | 2016-05-18 | — | — | EP | disclosed |
| EP-2199323-B1 | Anti-frost film assemblies, method of manufacture, and articles made thereof | SABIC GLOBAL TECHNOLOGIES BV (NL) | 2016-04-13 | — | — | EP | disclosed |
| WO-2015088582-A1 | COATING COMPOSITIONS COMPRISING A BLOCKED ISOCYANATE SILANE | SDC TECHNOLOGIES, INC. (US) | 2015-06-18 | — | — | WO | disclosed |
| US-20150166827-A1 | COATING COMPOSITIONS COMPRISING A BLOCKED ISOCYANATE SILANE | SDC TECHNOLOGIES, INC. (US) | 2015-06-18 | — | — | US | disclosed |
| EP-2199323-A1 | Anti-frost film assemblies, method of manufacture, and articles made thereof | SABIC Innovative Plastics B.V. (NL) | 2010-06-23 | — | — | EP | disclosed |
| EP-1928942-B1 | ANTI-FROST FILM ASSEMBLIES, METHOD OF MANUFACTURE, AND ARTICLES MADE THEREOF | SABIC GLOBAL TECHNOLOGIES BV (NL) | 2010-04-14 | — | — | EP | disclosed |
| EP-1928942-A1 | ANTI-FROST FILM ASSEMBLIES, METHOD OF MANUFACTURE, AND ARTICLES MADE THEREOF | General Electric Company (US) | 2008-06-11 | — | — | EP | disclosed |
| WO-2007041466-A1 | ANTI-FROST FILM ASSEMBLIES, METHOD OF MANUFACTURE, AND ARTICLES MADE THEREOF | GENERAL ELECTRIC COMPANY (US) | 2007-04-12 | — | — | WO | disclosed |
| WO-2007040941-A1 | ANTI-FOG FILM ASSEMBLIES, METHOD OF MANUFACTURE, AND ARTICLES MADE THEREOF | GENERAL ELECTRIC COMPANY (US) | 2007-04-12 | — | — | WO | disclosed |
| US-20070077399-A1 | Anti-fog film assemblies, method of manufacture, and articles made thereof | CITIBANK, N.A., AS COLLATERAL AGENT | 2007-04-05 | — | — | US | disclosed |
| EP-0914364-B1 | SCRATCH-RESISTANT ANTI-FOG COATING COMPOSITION INCORPORATING ISOCYANATE-REACTIVE SURFACTANTS | FILM SPECIALTIES INC (US) | 2006-12-20 | — | — | EP | disclosed |
| EP-0914364-A4 | SCRATCH-RESISTANT ANTI-FOG COATING COMPOSITION INCORPORATING ISOCYANATE-REACTIVE SURFACTANTS | FILM SPECIALTIES INC (US) | 1999-09-29 | — | — | EP | disclosed |
| EP-0914364-A1 | SCRATCH-RESISTANT ANTI-FOG COATING COMPOSITION INCORPORATING ISOCYANATE-REACTIVE SURFACTANTS | FILM SPECIALTIES, INC. (US) | 1999-05-12 | — | — | EP | disclosed |
| US-5877254-A | Scratch-resistant anti-fog coating composition incorporating isocyanate-reactive surfactants | FILM SPECIALTIES, INC. (US) | 1999-03-02 | — | — | US | disclosed |
| WO-1998003575-A1 | SCRATCH-RESISTANT ANTI-FOG COATING COMPOSITION INCORPORATING ISOCYANATE-REACTIVE SURFACTANTS | FILM SPECIALTIES, INC. (US) | 1998-01-29 | — | — | WO | disclosed |
| US-5007955-A | Applying quaternary ammonium sulfonates to weeds | DAI-ICHI KOGYO SEIYAKU CO., LTD. (JP) | 1991-04-16 | — | — | US | disclosed |