Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 10/20 | 0.58 |
| ▸ | SLC6A4 | P31645 | 10/20 | 0.58 |
| ▸ | KCNH2 | Q12809 | 10/20 | 0.58 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.55 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.41 |
| ▸ | PPARA | Q07869 | 3/20 | 0.40 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 2/20 | 0.40 |
| ▸ | PPARD | Q03181 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dimethylamine SCHEMBL27666829 | 0.86 | SLC6A4 (0.58) | HTR2ASLC6A4KCNH2SOS1MAPT | |
| SCHEMBL4345160 | 0.84 | SOS1 (0.65) | HTR2ASLC6A4KCNH2SOS1EGFR | |
| Dimethylamine SCHEMBL27645822 | 0.83 | HTR2A (0.54) | HTR2ASLC6A4KCNH2SOS1MAPT | |
| SCHEMBL10875782 | 0.81 | SOS1 (0.58) | HTR2ASLC6A4KCNH2SOS1EGFR | |
| SCHEMBL14662201 | 0.79 | SOS1 (0.60) | HTR2ASLC6A4KCNH2SOS1EGFR | |
| SCHEMBL1979103 | 0.78 | SOS1 (0.63) | HTR2ASLC6A4KCNH2SOS1EGFR | |
| SCHEMBL26601050 | 0.78 | SOS1 (0.58) | HTR2ASLC6A4KCNH2SOS1EGFR | |
| SCHEMBL10876069 | 0.78 | SOS1 (0.58) | HTR2ASLC6A4KCNH2SOS1EGFR | |
| SCHEMBL14396817 | 0.78 | SOS1 (0.54) | HTR2ASLC6A4KCNH2SOS1EGFR | |
| SCHEMBL4371877 | 0.78 | NPC1 (0.46) | HTR2ASLC6A4KCNH2SOS1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1878546-A | Combination comprising an alpha-2 delta ligand and an SSRI and/or SNRI for the treatment of depression and anxiety | WARNER LAMBERT CO (US) | 2006-12-13 | — | — | CN | claimed |